Correlation between choroidal thickness and WMH in patients with recent small subcortical infarct based on optical coherence tomography
10.3969/j.issn.1009-0126.2024.09.018
- VernacularTitle:近期皮质下小梗死患者眼底脉络膜厚度与脑白质高信号的相关性研究
- Author:
Kaidi CUI
1
;
Min ZHANG
;
Wenwei YUN
;
Chenyan ZHANG
Author Information
1. 213000 南京医科大学附属常州市第二人民医院神经内科
- Keywords:
brain infarction;
choroid;
magnetic resonance imaging;
white matter hyperintensity
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2024;26(9):1065-1068
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between choroidal thickness and white matter hyperintensity(WMH)in patients with recent subcortical small infarct(RSSI).Methods A total of 83 RSSI patients hospitalized in our hospital from November 2021 to May 2023 were enrolled,and according to paraventricular WMH,they were divided into no to mild lesion group 1(46 cases)and moderate to severe lesion group 1(37 cases),and based on deep WMH,40 of them were assigned into no to mild lesion group 2 and 43 cases into moderate to severe lesion group 2.All patients underwent cranial MRI for paraventricular WMH and deep WMH,and optical coher-ence tomography to measure choroid thickness by semi-automatic segmentation.The relationship between choroidal thickness and WMH at paraventricular and deep parts was analyzed.Results Significant advanced age,higher proportions of smoking and hypertension,and larger volume of deep WMH,while obviously thinner choroid thickness were observed in the moderate to severe lesion group 2 than the no to mild lesion group 2(P＜0.05,P＜0.01).While the moder-ate to severe lesion group 1 had older age,higher smoking and hypertension ratios,and higher volume of paraventricular WMH when compared with the no to mild group 1(P＜0.05,P＜0.01).Multivariate logistic regression analysis showed that age(OR=1.170,95％CI:1.064-1.287,P=0.001),hypertension(OR=4.533,95％CI:1.215-16.914,P=0.024),and choroidal thickness(OR=0.953,95％CI:0.931-0.975,P=0.001)were independent risk factors for deep WMH grade.Conclusion Changes in choroidal thickness in RSSI patients are independent influ-encing factors for severity of deep WMH lesions.The more severe the deep WMH lesion is,the thinner the choroidal thickness.
