Clinical analysis of new-onset epilepsy in elderly dementia
10.3969/j.issn.1009-0126.2024.08.018
- VernacularTitle:老年期痴呆新发癫痫的临床分析
- Author:
Yanshu WANG
1
;
Jiachen LI
;
Qing XIA
;
Yanfei PAN
;
Xianzeng LIU
Author Information
1. 102206 北京大学国际医院神经内科
- Keywords:
Alzheimer disease;
epilepsy;
electroencephalography;
anticonvulsants
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2024;26(8):939-941
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the etiology,types,treatment,and prognosis of new-onset epilep-sy in elderly dementia.Methods A retrospective analysis was conducted on 45 new-onset epilepsy in elderly dementia admitted to our department from January 2017 to December 2023.According to their etiology,they were divided into a degenerative dementia group(with AD as the main cause,AD dementia group,24 cases,)and a non-degenerative dementia group(non-AD dementia group,21 cases).Seizure types and and electroencephalogram(EEG)findings were compared be-tween the two groups.The medication and efficacy were also compared between the two groups in 3 months after treatment with antiepileptic drugs.Results Each patient had at least one type of seizure.The AD dementia group had a lower incidence of generalized seizure,but higher incidences of focal seizure and non-convulsive seizure(NCS)when compared with the non-AD dementia group(P＜0.05,P＜0.01).At least one type of abnormal EEG findings was observed in each pa-tient,but there was no statistical difference in the occurrence of EEG abnormalities between the two groups(P＞0.05).Among the 45 patients,42(93.3％)received antiepileptic drugs,and 38(90.5％)patients were well controlled,with the AD dementia group having a higher effective rate of single antiepileptic drug than the non-AD dementia group(95.5％vs 85.7％,P＜0.05).Conclu-sion Dementia combined with epilepsy(especially NCS)is often hard to detect,and continuous EEG monitoring is essential for elderly dementia patients.Most new-onset epilepsy in elderly de-mentia can be effectively controlled through antiepileptic drug therapy.
