Correlation of miR-497-5p and miR-331-5p levels and neurological deficit in ischemic stroke patients
10.3969/j.issn.1009-0126.2024.08.012
- VernacularTitle:微小RNA-497-5p和微小RNA-331-5p与缺血性脑卒中患者神经功能缺损程度的相关性
- Author:
Tao TANG
1
;
Min CHEN
;
Shangying YAO
;
Yan SONG
Author Information
1. 473000 南阳医学高等专科学校第一附属医院神经内科一病区
- Keywords:
stroke;
neurologic manifestations;
depression;
forecasting;
circulating microRNA
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2024;26(8):911-915
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between plasma miR-497-5p and miR-331-5p levels and the severity of neurological deficit and incidence of post-stroke depression(PSD)in pa-tients with ischemic stroke(IS).Methods A total of 191 IS patients attended to the First Affilia-ted Hospital of Nanyang Medical College from July 2021 to July 2023 were enrolled as the study group,and another 191 healthy individuals who taking physical examination in the same period were recruited as the control group.According to the NIHSS score,the patients were divided into mild,moderate and severe neurological deficit subgroups(82,68 and 41 cases,respectively),while according to the results of Hamilton Depression Scale,112 cases were assigned into a non-PSD subgroup and 79 cases into a PSD subgroup.Pearson and Spearman correlation analyses were used to analyze the correlation between plasma miR-497-5p and miR-331-5p levels and NIHSS score.Multivariate logistic regression analysis was employed to identify the risk factors for the occur-rence of PSD in IS patients,and ROC curve was plotted to evaluate the predictive values of plasma miR-497-5p and miR-331-5p levels for the occurrence of PSD in IS patients.Results The plasma miR-497-5p and miR-331-5p levels were significantly higher in the study group than the control group(P＜0.01).The levels and NIHSS score were significantly increase in the mild,moderate and severe neurological deficit subgroups in order(P＜0.01).The two levels and NIHSS score were all positively correlated(P＜0.01).The PSD group had more severe deficiency,and higher levels of miR-497-5p and miR-331-5p than the non-PSD group(P＜0.01).Multivariate logistic regression analysis showed,the plasma miR-497-5p and miR-331-5p levels and severe deficiency were risk factors for the occurrence of PSD in IS patients(OR=3.248,95％CI:1.623-6.501;OR=4.258,95％CI:1.739-10.428;OR=2.261,95％CI:1.261-4.055).The AUC value of miR-497-5p,miR-331-5p and their combined together for predicting the occurrence of PSD in IS patients was 0.836,0.817 and 0.911,respectively,with the value of combined indicators was supe-rior to that of single one(P＜0.05).Conclusion Plasma miR-497-5p and miR-331-5p levels are significantly elevated in IS patients,which are closely associated with the severity of neurological deficits and the occurrence of PSD.Their combination shows a good predictive value for the occur-rence of PSD in IS patients.
