Relationship of blood routine and coagulation related indicators with early progression of ACI in patients with BAD
10.3969/j.issn.1009-0126.2024.08.011
- VernacularTitle:血常规及凝血相关指标与急性穿支动脉粥样硬化性脑梗死早期病情进展关系的研究
- Author:
Jing YUN
1
;
Chunying DENG
;
Junqin ZUO
;
Xiaoyu CUI
;
Jiao ZHENG
;
Bin LIU
;
Wenjing MAO
Author Information
1. 063000 唐山,华北理工大学附属医院神经内一科
- Keywords:
brain infarction;
mean platelet volume;
partial thromboplastin time;
fibrinogen
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2024;26(8):906-910
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation of MPV,NLR,PT,APTT and FIB with early pro-gression of ACI in patients with BAD.Methods A total of 303 ACI patients with BAD admitted in our department of neurology from October 2021 to September 2023 were consecutively recrui-ted,and according to their progression within 7 d of onset,they were divided into progression group(89 cases)and un-progression group(214 cases).The general clinical data,blood routine re-lated indicators(MPV,NLR)and coagulation related indicators(PT,APTT,FIB)were compared between the two groups.Multivariate logistic regression analysis was applied to identify the rela-tionship of above indicators with early progression of ACI in BAD patients.ROC curve was plot-ted to analyze the predictive value of the indictors for disease progression in these patients.Results The progression group had significantly advanced age,larger proportions of diabetes,hyperlipi-demia and stroke history,and increased levels of uric acid,LDL-C,homocysteine,MPV,platelet distribution width,NLR,D-dimer and FIB,and shorter TT,PT and APTT when compared with the un-progressed group(P＜0.05,P＜0.01).Multivariate logistic regression analysis showed that MPV,NLR,PT,APTT,and FIB were all independent influencing factors for early disease pro-gression of ACI in patients with BAD(P＜0.05,P＜0.01).ROC curve indicated that the AUC value of combined MPV,NLR,PT,APTT and FIB in detecting early disease progression was 0.859(95％CI:0.813-0.905).Conclusion Blood routine(MPV,NLR)and coagulation related indicators(PT,APTT,FIB)are closely associated with the early disease progression of ACI in BAD patients,and these indicators are of high value in predicting the early disease progression.
