Longitudinal analysis of perioperative serum inflammatory factors in patients with HICH and correlation with prognosis
10.3969/j.issn.1009-0126.2024.08.010
- VernacularTitle:高血压性脑出血患者围术期血清炎性因子水平纵向分析及其与预后的相关性
- Author:
Jing LIU
1
;
Jin WANG
;
Wenyan LIU
;
Xinwang CAI
;
Xiang XU
Author Information
1. 063000 唐山市工人医院神经外二科
- Keywords:
intracranial hemorrhage,hypertensive;
perioperative period;
interleukin-6;
tumor necro-sis factor-alpha;
prognosis;
correlation of data
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2024;26(8):902-905
- CountryChina
- Language:Chinese
-
Abstract:
Objective To longitudinally analyze the perioperative serum levels of inflammatory fac-tors in patients with hypertensive intracerebral hemorrhage(HICH),and to explore their correla-tion with prognosis.Methods A total of 173 HICH patients admitted to our hospital from Febru-ary 2021 to January 2023 were consecutively enrolled.Their serum levels of inflammatory factors were measured before operation,and in 6,12,24,48 and 72 h after operation.All of them were fol-lowed up for 6 months,and according to their prognosis,they were divided into good prognosis group(116 patients)and poor prognosis group(57 patients).Multivariate logistic regression anal-ysis was applied to analyze the correlation of the perioperative serum inflammatory factors with HICH prognosis.Results In these HICH patients,IL-6 and IL-1β were increased continuously within 72 h after operation,and the TNF-α level reached its peak at 48 h after operation.The poor prognosis group had significantly longer time from bleeding to admission(6.32±1.50 h vs 5.14±2.00 h),larger hematoma[35.50(24.50,46.00)ml vs 30.00(21.00,41.50)ml],and higher ratio of hematoma breaking into ventricles(28.07％vs 2.59％),and lower GCS score at admission(10.07±1.32 vs 11.00±0.85)when compared with the good prognosis group(P＜0.05,P＜0.01).Multivariate logistic regression analysis showed that the levels of IL-6,IL-1β and TNF-α at different postoperative time points were independent influencing factors for poor prognosis of HICH patients(P＜0.05,P＜0.01).Conclusion Serum levels of inflammatory factors IL-6,IL-1βand TNF-α are all elevated in HIGH patients during perioperative period,and their increments at different time points are correlated with the increased risk of adverse prognosis in the patients within 6 months after operation.
