Effect of immune-related plasma proteins under genetic regulation on Parkinson's disease
10.3969/j.issn.1009-0126.2024.07.018
- VernacularTitle:遗传调控下免疫相关血浆蛋白对帕金森病的效应
- Author:
Zihao WANG
1
;
Peishan LI
;
Huan XIA
;
Xinyu DU
;
Kelibinuer·Saidierding
;
Xinling YANG
Author Information
1. 830000 乌鲁木齐,新疆医科大学第二附属医院重点实验室
- Keywords:
Parkinson disease;
cathepsin B;
blood proteins;
cerebral dopamine neurotrophic factor;
hemoglobin beta subunit;
single-cell sequencing;
immunoglobulin G Fc receptor 2a(FCGR2A)
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2024;26(7):806-810
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the connection between immune-related plasma proteins and Parkinson's disease.Methods By analyzing genome-wide association study data of 4907 immune-related plasma proteins,we assessed their direct impact on the risk of Parkinson's disease.Single-nucleus RNA sequencing data were also utilized for protein expression analysis.Results Four im-mune-related proteins,cerebral dopamine neurotrophic factor(CDNF),cathepsin B(CTSB),im-munoglobulin G Fc receptor 2a(FCGR2A),and hemoglobin beta subunit(HBB),were identified to be associated with the risk of Parkinson's disease.Among them,increased expression levels of CDNF,CTSB and HBB were found to decrease the risk(OR=0.871,95％CI:0.779-0.973,P=0.015;OR=0.835,95％CI:0.758-0.920,P=0.001;OR=0.735,95％CI:0.631-0.857,P=0.001),whereas increased level of FCGR2A was associated with a higher risk of PD(OR=1.137,95％CI:1.058-1.223,P=0.001).Singl e-cell sequencing analyzes protein expression and its dis-tribution among different cell types in the brain.CDNF and CTSB exhibit high expression levels in multiple brain cell types,FCGR2A is predominantly expressed in brain microglia and HBB shows minimal expression in the brain.Conclusion There are potential links between the four proteins CDNF,CTSB,FCGR2A and HBB and the risk of Parkinson's disease.Our results emphasize that the genetic risk variants of Parkinson's disease influence the disease's occurrence by modulating the expression of these immune-related proteins.Additionally,single-cell expression data reveal the expression patterns of these target proteins in the brain.
