Correlation of claudin-5 level with risk of hemorrhage transformation in elderly stroke patients after thrombolysis
10.3969/j.issn.1009-0126.2024.07.016
- VernacularTitle:紧密连接蛋白5水平与老年脑卒中患者溶栓后出血转化风险的相关性
- Author:
Li WANG
1
;
Haoyuan MA
;
Litao GAO
;
Yu XU
;
Jialan YAN
Author Information
1. 050081 石家庄,联勤保障部队第九八○医院神经内科
- Keywords:
stroke;
tight junction proteins;
thrombolytic therapy;
hemorrhage;
risk factors;
logistic models;
correlation of data
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2024;26(7):798-801
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between claudin-5 level and the risk of hemor-rhagic transformation(HT)in elderly stroke patients after thrombolysis.Methods A total of 192 elderly stroke patients hospitalized in our department from February 2021 to October 2022 were recruited,and divided into HT group(32 cases,including 14 of parenchymal hematoma type and 18 of hemorrhagic cerebral infarction type)and non-HT group(160 cases)according to the results of head CT or MRI 48 h after thrombolysis.The clinical data and serum claudin-5 level were com-pared between the two groups.Multivariate logistic regression analysis was used to identify the in-fluencing factors of HT risk after thrombolysis in elderly stroke patients.Restricted cubic splines were drawn to analyze the correlation between claudin-5 level and HT risk after thrombolysis.Re-sults The HT group had higher proportion of atrial fibrillation,longer onset to thrombolysis time,higher baseline NIHSS score,and fasting blood glucose and claudin-5 levels than the non-HT group(P＜0.05,P＜0.01).Multivariate logistic regression analysis showed that time from onset to thrombolysis(OR=2.589,95％CI:1.202-5.573,P=0.015),baseline NIHSS score(OR=1.415,95％CI:1.213-1.651,P=0.000),and fasting blood glucose(OR=1.552,95％CI:1.014-2.375,P=0.043)and claudin-5 levels(OR=1.174,95％CI:1.076-1.281,P=0.000)were risk factors for HT after thrombolysis in elderly stroke patients.Restricted cubic spline anal-ysis demonstrated that claudin-5 level had a nonlinear relationship with the risk of HT in the pa-tients after thrombolysis(x2=12.380,P=0.006).Conclusion Serum claudin-5 level is associated with HT after thrombolysis in elderly stroke patients,and shows a dose-response relationship with HT.
