Influence of Qishen Yiqi dropping pills on serum IL-18 level and prognosis in elderly hypertension patients with acute coronary syndrome
10.3969/j.issn.1009-0126.2024.07.010
- VernacularTitle:芪参益气滴丸对老年高血压合并急性冠状动脉综合征患者血清白细胞介素18及预后的影响
- Author:
Dujing SHAO
1
;
Naikuan FU
;
Yujie LIU
;
Xiaogang LIU
;
Ying ZHANG
Author Information
1. 300222 天津市胸科医院(天津大学胸科医院)心内科
- Keywords:
hypertension;
acute coronary syndrome;
interleukin-18;
prognosis;
Qi Shen Yi Qi Di Wan
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2024;26(7):769-773
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influences of Qishen Yiqi dropping pills on serum IL-18 level and prognosis in elderly hypertension patients complicated with acute coronary syndrome(ACS).Methods A prospective study was performed on 330 patients with hypertension compli-cated by ACS treated in our hospital from January 2020 to January 2022.They were randomly di-vided into dropping pills treatment group(n=164)and control group(n=166).The control group received standard Western medicine treatment,and on the basis of the treatment,the treat-ment group were given Qishen Yiqi dropping pills.The baseline clinical data,serum IL-18 level,blood pressure,and blood lipid and glucose levels in 1 year after treatment and the incidence rate of MACE within 1 year of follow-up were compared between the two groups.Multivariate logistic regression analysis was applied to identify influencing factors for reoccurrence of MACE in elderly patients with hypertension complicated by ACS.ROC curve was plotted to study the value of IL-18 in predicting MACE in the patients.Results In 1 year after treatment,SBP and DBP levels,serum levels of IL-18,LDL-C and TC,and the incidence of MACE were significantly lower in the treatment group than the control group(P＜0.05).Multivarate logistic regression analysis re-vealed that Qishen Yiqi dropping pill was an independent protective factor for MACE(OR=0.259,95％CI:0.087-0.772,P=0.010),while higher serum IL-18 level was a risk factor for MACE(OR=1.075,95％CI:1.046-1.106,P=0.000)in the elderly hypertension patients com-plicated by ACS.The AUC value of serum IL-18 level in predicting MACE in the patients with hypertension complicated by ACS was 0.786(95％CI:0.696-0.877,P＜0.01),with a sensitivity and a specificity of 65.00％and 90.00％respectively.Conclusion Serum IL-18 level has a predic-tive value for prognosis in elderly hypertension patients complicated with ACS.Qishen Yiqi drop-ping pills can reduce serum IL-18 level,blood pressure and lipids,attenuate inflammatory re-sponse,and consequently decrease the risk of MACE and improve prognosis in the patients.
