Correlation of genetic polymorphisms with risk of rivaroxaban-associated bleeding events in very old patients with nonvalvular atrial fibrillation
10.3969/j.issn.1009-0126.2024.07.007
- VernacularTitle:高龄非瓣膜性心房颤动患者遗传多态性与利伐沙班出血事件风险的相关性
- Author:
Peng LI
1
;
Cunyu LIANG
;
Huanhuan DING
;
Juan WANG
Author Information
1. 830011 乌鲁木齐,新疆医科大学第五附属医院心内科
- Keywords:
atrial fibrillation;
genotype;
rivaroxaban;
hemorrhage;
genetic polymorphisms of CYP2C9;
genetic polymorphisms of VKORC1
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2024;26(7):755-758
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between genetic polymorphisms and the risk of rivaroxaban bleeding events in elderly patients with nonvalvular atrial fibrillation(NVAF).Meth-ods A total of 180 elderly NVAF patients treated with rivaroxaban in our department from June 2019 to June 2022 were enrolled,and after 1 year of follow-up,finally,167 patients were included,according to whether bleeding events occurred,they were divided into hemorrhage group(n=31)and control group(n=136).The clinical data and genetic polymorphism were compared between the two groups.Multivariate logistic regression was used to analyze the association between genet-ic polymorphisms and bleeding events in the patients after rivaroxaban treatment.Results Higher frequencies of CYP2C9*1,CYP2C9*3 and VKORC1-GG,but lower frequencies of CYP2C9*2,VKORC1-AA and VKORC1-AG were observed in the bleeding group than the control group(all P＜0.01).Multivariate logistic regression analysis showed that CYP2C9*1,CYP2C9*3 and VKORC1-GG were independent risk factors for bleeding events in elderly NVAF patients taking rivaroxaban(OR=1.880,95％CI:1.126-1.997,P=0.030;OR=1.432,95％CI:1.044-1.964,P=0.026;OR=2.176,95％CI:1.173-4.037,P=0.014),while,CYP2C9*2,VKORC1-AA and VKORC1-AG were protective factors for bleeding events in elderly NVAF patients taking rivar-oxaban.Conclusion Genetic polymorphisms of CYP2C9 and VKORC1 are significantly correlated with the risk of bleeding events in elderly NVAF patients taking rivaroxaban.And CYP2C9*1,CYP2C9*3 and VKORC1-GG genotypes are independent risk factors,while CYP2C9*2,VKORC1-AA and VKORC1-AG genotypes are protective factors.
