Correlation between triglyceride-glucose index and prognosis in very old patients with decompensated heart failure
10.3969/j.issn.1009-0126.2024.07.005
- VernacularTitle:三酰甘油葡萄糖指数与高龄失代偿性心力衰竭患者预后的相关性
- Author:
Jingxian LIAO
1
;
Xiaozhu SHEN
;
Lei MIAO
Author Information
1. 222000 连云港市第二人民医院老年医学科
- Keywords:
heart failure;
prognosis;
forecasting;
correlation of data;
triglyceride-glucose index
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2024;26(7):746-750
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of triglyceride-glucose(TyG)index on the prognosis of elderly patients with decompensated heart failure(HF).Methods Clinical data of 305 patients(≥75 years old)with decompensated HF admitted to our hospital from January 2020 to Decem-ber 2023 were collected and retrospectively analyzed.According to the median TyG index,they were divided into high TyG index group(≥9.11,n=155)and low TyG index group(＜9.11,n=150).The results of laboratory tests,ambulatory blood pressure monitoring(ABPM),and echo-cardiography(ECG)were obtained from the electronic medical record system of our hospital.All patients were followed up by telephone within 28 d after discharge.The clinical characteristics were compared between the two groups.Spearman correlation analysis was used to analyze the re-lationship of TyG index with cardiac function and ABPM indicators of the patients.Kaplan-Meier survival curve was plotted to analyze the influence of the TyG index on the prognosis,and ROC curve was drawn to analyze the predictive value of the TyG index for 28-day mortality in these elderly patients.Results The high TyG index group had significantly higher mortality,thicker in-terventricular septum thickness(IVST),larger proportions of diabetes and hypertension,and higher levels of fasting blood glucose,cholesterol,triacylglycerol,NT-proBNP and coefficients of variation(CV)in 24-h SBP and 24-h DBP,and lower HDL-C level when compared to the low TyG index group(P＜0.05,P＜0.01).Spearman correlation analysis revealed that the TyG index was significantly positively correlated with IVST(r=0.526,P＜0.01),24-h SBP CV(r=0.342,P＜0.01),24-h DBP CV(r=0.302,P＜0.01)and NT-proBNP level(r=0.443,P＜0.01).Further-more,Kaplan-Meier survival analysis indicated that a significantly higher 28-day cumulative sur-vival rate was observed in the low TyG index group than the high TyG index group(94.67％vs 83.23％,log rank X2=10.436,P=0.001).Additionally,ROC curve analysis showed that the AUC value of TyG index in predicting 28-day mortality in elderly patients with decompensated HF was 0.692(95％CI:0.597-0.786).When the cutoff value of TyG inde x was 9.22,the sensitivity was 76.50％,and the specificity was 63.50％.Conclusion High TyG index indicates poor prognosis in elderly patients aged over 75 years with decompensated HF,and increment of TyG index may be helpful to identify high-risk HF population.
