Correlation of asymptomatic carotid stenosis and cerebral white matter hyperintensity volume in the elderly population
10.3969/j.issn.1009-0126.2024.06.015
- VernacularTitle:老年人群无症状性颈动脉狭窄与脑白质高信号体积的相关性研究
- Author:
Guisong ZHANG
1
;
Wei BU
;
Yanan JIA
;
Ling YANG
;
Wenjun LI
;
Huiling REN
Author Information
1. 050051 石家庄,河北医科大学第三医院神经内科
- Keywords:
carotid stenosis;
risk factors;
cerebral white matter hyperintensity;
generalized linear model
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2024;26(6):665-669
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between aCAS and the location and volume of cerebral WMH in the elderly people.Methods A total of 188 elderly WMH patients admitted to our hospital from September 2022 to September 2023 were enrolled and divided into no or mild(stenosis≤49％,137 cases),moderate(50％-69％,25 cases),and severe aCAS groups(≥70％,26 cases)according to the degree of carotid stenosis.All of the patients underwent cranial MRI scanning to assess total,periventricular,deep,and juxtacortical WMH volumes.Univariate and multivariate generalized linear model analyses were used.Results The moderate and severe aCAS groups had significantly older age,larger proportions of coronary heart disease and smoking,and higher total,peri ventricular,and juxtacortical WMH volumes than the no or mild aCAS group,and the deep WMH in the severe aCAS group was higher than that in the no or mild aCAS group(P＜0.05).Multivariate generalized linear model analysis showed that both moderate and severe aCAS were independent risk factors for total WMH volume(OR=325.629,95％CI:24.255-4371.608;OR=51.088,95％CI:4.135-631.128),periventricular WMH volume(OR=27.655,95％CI:5.168-147.976;OR=8.988,95％CI:1.754-46.051),deep WMH volume(OR=3.641,95％CI:1.511-8.774;OR=2.589,95％CI:1.105-6.064)and juxtacortical WMH volume(OR=3.005,95％CI:1.831-4.933;OR=2.199,95％CI:1.36-3.566)(P＜0.05,P＜0.01).Conclusion aCAS is an independent risk factor for WMH in the elderly population,and stenosis＞50％has a greater correlation with WMH volume.
