Correlation of neutrophil,high-density lipoprotein cholesterol and lipoprotein(a)with stroke in elderly patients with AF
10.3969/j.issn.1009-0126.2024.06.013
- VernacularTitle:中性粒细胞和高密度脂蛋白胆固醇及脂蛋白(a)与老年心房颤动患者合并脑卒中的相关性
- Author:
Jiongchao GUO
1
;
Yating HUANG
;
Minmin FU
;
Bingfeng ZHOU
;
Xiaohong ZHANG
Author Information
1. 230001 合肥市第一人民医院心血管内科
- Keywords:
atrial fibrillation;
stroke;
neutrophils;
cholesterol,HDL;
lipoprotein(a);
correlation of data
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2024;26(6):657-660
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of neutrophil to high-density lipoprotein cho-lesterol ratio(NHR)and lipoprotein(a)[Lp(a)]with occurrence of acute ischemic stroke(AIS)in elderly patients with non-valvular atrial fibrillation(NVAF).Methods A total of 301 elderly NVAF patients admitted to Hefei First People's Hospital from May 2020 to May 2023 were en-rolled,and according to whether they were combined with AIS or not,they were divided into stroke group(143 cases)and non-stroke group(158 cases).Binary logistic regression analysis was used to screen risk factors,and ROC curve was plotted to assess their predictive values for AIS.Results Lp(a)and NHR in stroke group were significantly higher than those in non-stroke group,the difference was statistically significant(P＜0.01).Multivariate binary logistic regression analysis showed that NHR and Lp(a)were independent risk factors for death with NVAF com-bined AIS(OR=1.728,95％CI:1.367-2.186,P=0.000;OR=1.005,95％CI:1.002-1.007,P=0.000);ROC curve analysis indicated that the AUC value of NHR and Lp(a)in diagnosing AIS in NVAF patients was 0.668 and 0.735,respectively,and that of their combination was 0.789,which was significantly higher than that of NHR and Lp(a)alone(P＜0.01).Conclusion NHR and Lp(a)are independently related to AIS in NVAF patients,and their combination has certain diagnos-tic efficacy.
