Predictive value of NT-proBNP and Lp(a)levels and coagulation function for deep venous thrombosis in chronic heart failure patients
10.3969/j.issn.1009-0126.2024.06.010
- VernacularTitle:N末端B型钠尿肽前体和脂蛋白(a)水平及凝血功能预测慢性心力衰竭并发深静脉血栓作用
- Author:
Xuelian LIU
1
;
Lina MOU
;
Shasha MA
;
Jiandong XIAO
;
Huijing ZHANG
Author Information
1. 053000 衡水市人民医院心血管内科
- Keywords:
heart failure;
venous thrombosis;
natriuretic peptide,lipoprotein(a);
blood coagulation;
forecasting;
logistic models
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2024;26(6):642-646
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the predictive value of combined serum levels of N-terminal pro-B-type natriuretic peptide(NT-proBNP)and lipoprotein(a)[Lp(a)]and coagulation function indicators for occurrence of deep venous thrombosis(DVT)in elderly patients with chronic heart failure(CHF).Methods A total of 230 elderly CHF patients admitted in Hengshui People's Hos-pital from January 25 to December 25,2022 were enrolled,and divided into a DVT group(76 ca-ses)and a non-DVT group(154 cases)based on the presence of DVT or not.And another 100 healthy individuals taking physical examination during the same period were included and served as the control group.The general information,clinical data,and coagulation indicators of each group were collected.Serum NT-proBNP and Lp(a)levels were measured with ELISA.Logistic regression analysis was used to determine the independent risk factors,and ROC curve was used to determine the predictive values of single and combined detection.Results The incidence of lower limb arteriosclerosis was significantly higher in the DVT group than that in the non-DVT group(P＜0.05),but there were no statistical differences in other data(P＞0.05).Platelet count and LDL in DVT group were higher than those in non-DVT group,and HDL was lower than those in non-DVT group(P＜0.05).The DVT group had notably shorter activated partial throm-boplastin time(aPTT),prothrombin time(PT)and thrombin time(TT),and remarkably higher FIB,D-dimer,NT-proBNP and Lp(a)levels when compared with the non-DVT group(P＜0.05).Logistic regression analysis showed that HDL,aPTT,FIB,D-dimer,NT-proBNP and Lp(a)were independent risk factors for DVT in elderly CHF patients(P＜0.05,P＜0.01).The obtained lo-gistic regression model was:Logit(P)=0.933X3+0.744X8+0.812X11+0.681X12+0.774X13+0.684X14.The combined regression model had an AUC value of 0.948(95％CI:0.918-0.977),a sensitivity of 89.47％and a specificity of 89.61％.Conclusion NT-proBNP,Lp(a),and coagula-tion function indicators are independent risk factors for DVT in elderly CHF patients,and com-bined detection has high predictive value.
