Diagnostic value of serum NGAL and GDF-15 levels for hypertension-induced renal injury in elderly patients
10.3969/j.issn.1009-0126.2024.06.007
- VernacularTitle:中性粒细胞明胶酶相关脂质运载蛋白和生长分化因子15在高血压肾损伤中的诊断价值
- Author:
Chi ZHANG
1
;
Zhijie DOU
;
Cong CUI
;
Jun LI
;
Jian ZHOU
Author Information
1. 067000 承德医学院附属医院神经内科
- Keywords:
hypertension;
growth differentiation factor 15;
acute kidney injury;
diagnosis;
neutro-phil gelatinase-associated lipocalin
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2024;26(6):628-631
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of combined serum levels of neutrophil gelatinase-associated lipocalin(NGAL)and growth differentiation factor 15(GDF-15)in diagnosis of renal injury in elderly patients with H-type hypertension.Methods A total of 177 patients with H-type hypertension admitted to Department of Neurology and Department of General Medicine of the Affiliated Hospital of Chengde Medical College from April 2021 to June 2022 were enrolled,and based on their estimated glomerular filtration rate(eGFR),they were divided into the renal im-pairment group(81 cases)and normal renal function group(96 cases).General data and laboratory indicators were collected in the two groups.ROC curve analysis was used to evaluate the diagnos-tic value of combined NGAL and GDF-15 levels for renal injury in the elderly patients with H-type hypertension,and Pearson correlation analysis was performed to analyze the correlation between serum NGAL and GDF-15 levels and renal injury in the patients.Results SBP level was significantly higher in the renal impairment group than the normal renal function group[148.53±14.62 mm Hg(1 mm Hg=0.133 kPa)vs 138.75±13.36 mm Hg,P＜0.01],but no such difference was observed in DBP level between the two groups(P＞0.05).The levels of creatinine(Cr),urea nitrogen(BUN),β2-microglobulin(β2-MG),cystatin C(Cys C),urinary microalbumin(MA),NGAL and GDF-15 levels were obviously higher in the renal impairment group than the group with normal renal function(P＜0.01).ROC curve analysis showed that the combined detection of NGAL and GDF-15 levels was significantly higher than that of the two indicators alone(P＜0.01).Pearson correlation analysis indicated that serum NGAL and GDF-15 levels were positively correlated with Cr,BUN,β2-MG,Cys C and MA levels(P＜0.01).Conclusion Serum NGAL and GDF-15 levels are elevated in elderly H-type hypertension patients.Combined detection of the two indicators has higher value in the diagnosis of renal injury in elderly H-type hypertension patients.
