Relationship between serum high mobility group protein B1 and anxiety symptoms in patients with cerebral small vessel disease
10.3969/j.issn.1009-0126.2024.05.015
- VernacularTitle:脑小血管病患者血清高迁移率族蛋白B1与焦虑症状的关系研究
- Author:
Wenhua DING
1
;
Yuwei WANG
;
Jingjing QIU
;
Yurong GENG
Author Information
1. 832000 石河子大学第一附属医院神经内科
- Keywords:
cerebral small vessel diseases;
anxiety;
high mobility group proteins;
logistic models;
forecasting
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2024;26(5):544-547
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between serum high mobility group protein B1(HMGB1)level and anxiety symptoms in patients with cerebral small vessel disease(CSVD).Methods A total of 165 CSVD patients admitted in our department from December 2022 to July 2023 were enrolled as the research subjects.All of them were evaluated by neurologists with Hamilton Anxiety Rating Scale(HAMA),and then those with HAMA score ≥7 were assigned into an anxiety group(70 cases),and the other into a non-anxiety group(95 cases).Non paramet-ric rank sum test was used to compare the serum level of HMGB1 between the two groups of pa-tients.Logistic regression analysis was employed to analyze the risk factors affecting anxiety symptoms in CSVD patients.ROC curve was plotted to evaluate the predictive value of HMGB1 for anxiety symptoms in the patients.Results The serum HMGB1 level was significantly higher in the anxiety group than the non-anxiety group[287.01(188.19,355.54)ng/L vs 260.87(146.48,328.16)ng/L,P＜0.05].Multivariate logistic regression analysis showed that after adjusting for confounding factors,serum HMGB1 level was still a risk factor for anxiety symptoms in CSVD patients(OR=1.004,95％CI:1.000-1.007,P=0.046).Spearman correlation analysis indicated that HMGB1 level was positively correlated with total score of HAMA,insomnia score,and psy-chogenic score(P＜0.05,P＜0.01).The AUC value of HMGB1 in predicting anxiety symptoms in CSVD patients was 0.609(P=0.020).Conclusion Serum HMGB1 level is associated with the oc-currence of anxiety symptoms in CSVD patients,and it has predictive value for the anxiety symp-toms in CSVD patients.
