Impact of hemoglobin on all-cause mortality risk in elderly patients with stable coronary artery disease after interventional therapy
10.3969/j.issn.1009-0126.2024.05.008
- VernacularTitle:血红蛋白水平对老年稳定性冠状动脉疾病患者介入治疗术后全因死亡风险的影响
- Author:
Yang LIU
1
;
Zuonian ZHANG
;
Zhiye WANG
;
Mengyuan NI
;
Zhaomin LU
;
Lihua ZHANG
;
Shengbiao ZHAO
;
Junjun LIU
Author Information
1. 210039 南京梅山医院神经内科
- Keywords:
coronary artery disease;
percutaneous coronaryintervention;
hemoglobins;
forecasting;
death;
risk
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2024;26(5):513-517
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the impact of hemoglobin(Hb)level on the risk of all-cause mortality in elderly patients with stable coronary artery disease(SCAD)treated by percutaneous coronary intervention(PCI).Methods A retrospective cohort study was conducted on 195 elderly SCAD patients treated by PCI in our hospital from June 2016 to December 2017,a total of 180 case were followed up.They were divided into four groups based on quartiles of Hb levels:Q1 group[≤122(108.28±12.53)g/L,n=47],Q2 group[122＜Hb≤137(130.07±4.33)g/L,n=43],Q3 group[137＜Hb≤148(142.67±3.10)g/L,n=46],and Q4 group[＞148(158.36±8.50)g/L,n=44].Their clinical data were collected and compared among the groups.All patients were followed up,with all-cause mortality as endpoint.Cox regression analysis was used to evaluate the impact of Hb level on all-cause mortality in elderly SCAD patients treated by PCI.Results For the 180 patients with complete follow-up,the median follow-up time was 703(415,1121)d,and the incidence of all-cause mortality was 10.00％(totally 18 deaths).And the incidence was 25.50％(12 deaths),7.00％(3 death),4.30％(2 deaths)and 2.30％(1 death)in Q1,Q2,Q3,and Q4 groups,respectively,with statistically significant differences(P＜0.01).Univariate Cox regression analysis showed age was a risk factor for all-cause death(P＜0.01),while Hb level,BMI,smoking history,dyslipidemia,and aspirin use were a risk facotr for all-cause death(P＜0.05,P＜0.01).Further multivariate Cox regression analysis revealed Hb level was a risk facotr for all-cause death(HR=0.96,95％CI:0.93-0.99,P＜0.01).The risk of all-cause mortality was 3.68 times higher in the Q1 group than the Q2 group(HR=3.68,95％CI:1.01-13.45,P＜0.05),and there was no correlation in the incidence between the Q3 and Q4 groups(P＞0.05).Conclusion Low Hb level is an independent predictor for all-cause mortality in elderly SCAD pa-tients after PCI.
