Relationship of galectin-3 and PLR with postoperative ventricular remodeling in patients over 75 years old with AMI
10.3969/j.issn.1009-0126.2024.05.006
- VernacularTitle:半乳糖凝集素3及血小板与淋巴细胞比值与75岁以上急性心肌梗死患者术后心室重构的关系
- Author:
Xingui ZHANG
1
;
Changhong WANG
;
Jin WANG
Author Information
1. 473000 南阳市第一人民医院全科医学科
- Keywords:
myocardial infarction;
ventricular remodeling;
galectin 3;
platelet to lymphocyte ratio
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2024;26(5):504-507
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes in peripheral blood galectin-3(Gal-3)and platelet to lymphocyte ratio(PLR)and their relationship with ventricular remodeling in elderly patients over 75 years old with acute myocardial infarction(AMI)after PCI.Methods A total of 86 AMI patients(aged ≥75 years)undergoing elective PCI in our hospital from March 2021 to September 2023 were recruited in this study.According to ventricular remodeling occurred or not after PCI,they were divided into ventricular remodeling group(39 cases)and non-ventricular remodeling group(47 cases).Gal-3 level and PLR were detected and calculated before and in 3 and 5 d after PCI,and the results were compared between the two groups.Multivariate logistic regression anal-ysis was used to analyze the relationship of Gal-3 and PLR with ventricular remodeling in elderly AMI patients after PCI,and ROC curve was plotted to study the predictive value of the two indi-cators for ventricular remodeling.Results In the elderly AMI patients,the levels of Gal-3 and PLR were decreased in 3 and 5 d after PCI than before operation,and the levels at 5 d were lower than those of 3 d after operation(P＜0.05).The ventricular remodeling group had obviously high-er levels of Gal-3 and PLR in peripheral blood than the non-ventricular remodeling group before and in 3 and 5 d after PCI(P＜0.05,P＜0.01).Multivariate logistic regression analysis showed that Gal-3(OR=1.986,95％CI:1.017-2.875,P=0.007)and PLR(OR=1.774,95％CI:1.132-2.428,P=0.014)were risk factors for ventricular remodeling in AMI patients after PCI.ROC curve indicated that the AUC value of combined Gal-3 and PLR before PCI in predicting ventricu-lar remodeling in the AMI patients after PCI was 0.882(95％CI:0.824-0.941),which was supe-rior to the value of the two indicator alone(P＜0.05).Conclusion The levels of Gal-3 and PLR in peripheral blood are lower in the elderly AMI patients after PCI than before PCI,and the two in-dicators are risk factors for ventricular remodeling in these patients after PCI.Combined detection of them has high predictive value for ventricular remodeling in the patients.
