Predictive value of three metabolites for acute kidney injury in elderly patients with acute myocardial infarction
10.3969/j.issn.1009-0126.2024.05.003
- VernacularTitle:三种代谢产物对老年急性心肌梗死患者发生肾损伤的预测价值
- Author:
Xiangrong LIN
1
;
Ziying WANG
;
Dayi XING
;
Jing HAN
;
Yu SHEN
;
Xin WANG
;
Xinwei YANG
;
Hong LIAN
Author Information
1. 030001 太原,山西医科大学第一临床医学院
- Keywords:
myocardial infarction;
acute kidney injury;
gluconic acid;
fumaric acid;
pseudouridine
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2024;26(5):490-494
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the predictive value of combined plasma gluconic acid(GA),fumaric acid(FA),and pseudouridine levels at admission for acute kidney injury(AKI)in elderly patients with acute myocardial infarction(AMI).Methods A total of 78 elderly AMI patients transferred from Emergency Department to Coronary Care Unit in Fuwai Hospital during Decem-ber 2021 and July 2022 were enrolled in this prospective study.They were divided into AKI group(40 cases)and non-AKI group(38 cases)according to whether they developed AKI during hospi-talization.Plasma levels of GA,FA and pseudouridine were quantitatively detected with liquid chromatography-tandem mass spectrometry.ROC curve was plotted to assess the predictive value of these three plasma metabolites for AKI in AMI patients.Multivariate logistic regression analy-sis was applied to analyze the clinical risk factors for AKI.Results There were no statistical differences in the plasma levels of GA,FA and pseudouridine between the AKI group and the non-AKI group(P＞0.05).ROC curve analysis revealed that the plasma levels of the three indicators had no predictive value for the development of AKI in elderly AMI patients(AUC=0.576,95％CI:0.449-0.704,P=0.246;AUC=0.595,95％CI:0.467--0.721,P=0.154;AUC=0.563,95％CI:0.435-0.692,P=0.337).Multivariate logistic regression analysis revealed that left ventricu-lar ejection fraction(LVEF)was an independent predictor for AKI development in elderly AMI patients(OR=0.923,95％CI:0.870-0.978,P=0.007).Conclusion Plasma GA,FA and pseud-ouridine cannot predict the development of AKI in elderly AMI patients,while,LVEF is an inde-pendent predictor for the development.
