Research advances in development of vaccines and antiviral drugs for dengue fever

VernacularTitle:登革热疫苗与抗病毒药物研究进展
Author: Yueli DUAN ¹ ; Xian ZHOU ; Xinyu WANG
Author Information

1. 腾冲市人民医院感染科，腾冲　679100
Keywords: Dengue; Dengue virus; Vaccine; antiviral drugs
From: Chinese Journal of Clinical Infectious Diseases 2024;17(4):312-320
CountryChina
Language:Chinese
Abstract: Dengue fever，caused by the dengue virus，is an acute viral infectious disease，which frequently outbreaks in tropical and subtropical regions worldwide，and has become a significant global health burden and threat. The development of dengue vaccines and antiviral drugs has made rapid and significant progress recently. The existing CYD-TDV vaccine is primarily suitable for individuals prior infection，while vaccines such as TAK-003 and Butantan-DV have demonstrated good safety and efficacy in uninfected individuals of different age groups；several other types of dengue vaccines have also entered clinical research stages. For antiviral drugs，an oral antiviral drug JNJ-1802 has shown significant antiviral activity against the dengue virus and good tolerability in clinical trials. It has now entered community field research to validate its effectiveness in real-world settings. Several other drugs are also under continuous development. This article reviews the research progress in the development of vaccines and antiviral drugs for dengue fever to provide reference for further study and clinical application.