Systematic review of the efficacy of vitamin D supplementation on age-related sarcopenia
10.3760/cma.j.cn115624-20240410-00288
- VernacularTitle:维生素D对增龄性肌肉衰减症影响的系统综述
- Author:
Liping MENG
1
;
Hongliang LI
;
Chang YANG
;
Xiaomin XU
;
Siyuan LIU
;
Mei HE
;
Kang YU
Author Information
1. 内蒙古蒙牛乳业（集团）股份有限公司，呼和浩特 011500
- Keywords:
Vitamin D;
Sarcopenia;
Age factors;
Musculoskeletal development;
Muscle mass;
Muscle function
- From:
Chinese Journal of Health Management
2024;18(11):861-868
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To consolidate the current evidences regarding the efficacy of vitamin D supplementation in age-related sarcopenia.Methods:In this systemic review, a comprehensive literature search of scientific research including journal articles and academic dissertations was performed in prominent databases such as PubMed, Web of Science, China National Knowledge Infrastructure (CNKI) and Wanfang Database platforms, spanning from January 31, 2014 to January 31, 2024. Two search protocols integrating keywords and citation tracking were adopted to ensure comprehensiveness of the literature. Using “vitamin D” “ergocalciferols” “cholecalciferol” “sarcopenia” “muscle mass” “muscle strength” “myopenia” “muscle loss” “muscle reduction” “gait speed” “grip strength” “handgrip” as the main key words, focusing on the systematic reviews, meta-analyses of randomized controlled trials (RCT), and individual RCT, the scientific evidence of individual vitamin D intervention on age-related sarcopenia was evaluated and summarized. Research concerning particular disease conditions, children and adolescents, menopausal women, athletes and other specific populations were excluded.Results:A initial search yielded 2 448 articles in Chinese or English. A total of 8 systemic reviews/meta-analysis and 22 individual RCT literatures were included in the final analysis. Although some earlier lower-quality studies reported subtle improvements in skeletal muscle strength with vitamin D supplementation, high-quality systematic reviews/meta-analysis over the past three years had not shown significant positive effects of vitamin D intervention on sarcopenia and its breakdown parameters, such as skeletal muscle mass, muscle strength, and muscle function. Furthermore, the efficiency was influenced to some extent by the participants′ baseline status, such as muscle health and vitamin D nutritional status.Conclusions:Present evidence does not robustly support the efficacy of sole vitamin D supplement on age-related sarcopenia. High-quality clinical trials are imperative to accumulate more robust evidence in the future.
