Correlation between longitudinal change trajectory of white blood cell and new-onset type 2 diabetes mellitus: a cohort study
10.3760/cma.j.cn115624-20240329-00245
- VernacularTitle:白细胞纵向变化轨迹与新发2型糖尿病的相关性
- Author:
Xinfeng WANG
1
;
Fei GAO
;
Ying SUN
;
Shaoyou JIA
;
Rui HU
;
Weifen CHEN
;
Jinyan REN
;
Yan WANG
Author Information
1. 青岛大学附属医院健康管理中心，青岛 266555
- Keywords:
Diabetes mellitus, type 2;
Leukocyte count;
Trajectory model;
Cohort studies
- From:
Chinese Journal of Health Management
2024;18(11):855-860
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between the longitudinal change trajectory of white blood cell (WBC) and new-onset type 2 diabetes mellitus(T2DM).Methods:It was a prospective cohort study. A total of 2 792 people who underwent health examinations at the Health Management Center of the Affiliated Hospital of Qingdao University from January 2019 to December 2023 for five consecutive years and met the research standards were selected as the study subjects. Group-based trajectory modeling (GBTM) was established. The target population was divided into three groups based on the longitudinal change trajectory of WBC: low-stable group, medium-stable group and high-stable group. The cumulative incidence of T2DM in the three groups were analyzed. Multivariate Cox proportional risk regression models were used to analyze the correlation between different WBC trajectory groups and the risk of T2DM in total population, males and females. A restricted cubic spline regression (RCS) model was used to analyze the dose-response relationship between baseline WBC and risk of T2DM.Results:The cumulative incidence rate of T2DM in low-stable group, medium-stable group and high-stable group increased gradually, which was 2.5%, 5.3% and 6.9%, respectively ( χ2=19.024, P<0.001). After adjusting for multiple confounding factors in the Cox proportional hazards regression model, no significant difference in the incidence risk of T2DM among the three WBC trajectory groups in males; While the hazard ratios in the high-stable and medium-stable group in women was 2.852(95% CI: 1.067-7.628) and 2.588 (95% CI: 1.133-5.912), respectively, when compared with that in the low-stable group (both P<0.05). RCS curve analysis showed a linear relationship between WBC and the risk of T2DM in female ( Pnon-linear=0.956), when the WBC count was>5.53×10 9/L, the risk of T2DM increased with the rise of WBC. Conclusion:Higher WBC trajectory is positively correlated with the risk of new-onset T2DM in female health examination population.
