Mortality and risk factors of COPD-related death in non-metastatic NSCLC patients
10.3760/cma.j.cn115624-20240407-00276
- VernacularTitle:非转移性非小细胞肺癌患者慢阻肺相关死亡率及其危险因素
- Author:
Guohua JIA
1
;
Xiangpan LI
Author Information
1. 武汉大学人民医院肿瘤中心，武汉 430060
- Keywords:
Pulmonary disease, chronic obstructive;
Lung neoplasms;
Carcinoma, non-small-cell lung;
Risk factors;
Mortality;
Non-cancer related death;
Survival
- From:
Chinese Journal of Health Management
2024;18(10):754-760
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the mortality and risk factors for chronic obstructive pulmonary disease (COPD)-related mortality in patients with non-metastatic non-small cell lung cancer (NSCLC).Methods:This retrospective cohort study included patients aged 18-80 diagnosed with NSCLC between 2010 and 2019 from the Surveillance, Epidemiology and End Results (SEER) database. Cohort 1 enrolled 89 621 cases of non-metastatic NSCLC to calculate COPD-related mortality; Cohort 2 included 71 949 elderly patients with non-metastatic NSCLC to investigate the risk factors of COPD-related mortality in non-metastatic NSCLC patients using a competing risks model.Results:COPD-related mortality rate was 2.86% among non-metastatic NSCLC patients . COPD-related mortality rate increased with age, with a COPD-related mortality rate of 3.24% in patients aged 60 to <80 years, accounting for 90.9% of COPD related deaths in the whole age group with non-metastatic NSCLC. In the univariate competing risks model, advanced age, male, white race, squamous cell carcinoma, negative lymph node metastasis, no surgical treatment, radiotherapy, no chemotherapy, low-income population and single were identified as risk factors for COPD-related mortality. The multivariate competing risks model revealed that advanced age (70-74 years old: HR=1.24, 95% CI: 1.09-1.42; 75-79 years old: HR=1.23, 95% CI: 1.07-1.41), squamous cell carcinoma ( HR=1.75, 95% CI: 1.60-1.92), radiotherapy ( HR=1.58, 95% CI: 1.41-1.70) were independent risk factors for COPD-related mortality (all P<0.05). Conclusions:COPD-related mortality rate is high in non-metastatic NSCLC patients. Aged over 70 years old, squamous cell carcinoma and radiotherapy are risk factors for COPD-related death.
