Association between plasma atherogenic index trajectories and risk of hypertension in health examination population
10.3760/cma.j.cn115624-20231029-00245
- VernacularTitle:健康体检人群血浆致动脉粥样硬化指数轨迹与高血压发病风险的相关性
- Author:
Yu ZHOU
1
;
Hui ZHAO
;
Cuicui WANG
;
Xueni JIA
;
Yulong ZHAO
;
Fengling XIN
Author Information
1. 大连医科大学附属第二医院健康管理中心，大连 116027
- Keywords:
Physical examination;
Plasma atherogenic index;
Hypertension;
Group-based trajectory modeling
- From:
Chinese Journal of Health Management
2024;18(8):587-592
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between plasma atherogenic index (AIP) trajectory and the risk of hypertension in health examination population.Methods:In this retrospective cohort study, a total of 15 389 subjects who had undergone health examinations at the Health Management Center of the Second Affiliated Hospital of Dalian Medical University three or more times from January 2012 to December 2022 were consecutively selected. The general data, anthropometric parameters and laboratory parameters were collected. The study population without hypertension at baseline inclusion was screened, and AIP trajectory groups of different genders were determined by group-based trajectory modeling. The baseline characteristics and the incidence of hypertension at the end of follow-up were observed in each AIP trajectory group of men and women. Cox proportional hazards regression models were used to analyze the association of AIP trajectories with the risk of hypertension.Results:Four AIP trajectory groups (low level group, low gain group, medium gain group and high gain group) were identified in both male and female subjects, with the highest incidence of hypertension in the low gain group (38.18% in females and 40.92% in males). After adjusting for all confounders, the risk of hypertension was positively associated with increased AIP trajectories in the low ( HR=1.29, 95% CI: 1.02-1.63), medium ( HR=1.66, 95% CI: 1.23-2.23), and high ( HR=1.89, 95% CI: 1.26-2.85) gain groups in women; the risk of hypertension was positively associated with increased AIP trajectories in only the high gain group in men ( HR=1.33, 95% CI: 1.01-1.74). Conclusion:Elevated AIP trajectory is positively correlated with the risk of hypertension in health examination population.
