Nonlinear mixed-effects modeling method for evaluating dose-response relationship of 99Tc m-DMSA in pediatric renal static imaging
10.3760/cma.j.cn321828-20240124-00033
- VernacularTitle:应用非线性混合效应建模法评估 99Tc m-DMSA用于儿童肾静态显像的量-效关系
- Author:
Lisi XIE
1
;
Min WU
;
Zhaoyang WANG
;
Lei FANG
;
Tao LIU
;
Mei LI
;
Huan LI
;
Fang WANG
;
Yang WANG
Author Information
1. 华中科技大学同济医学院附属武汉儿童医院(武汉市妇幼保健院)核医学科，武汉 430016
- Keywords:
Dose-response relationship, radiation;
Radionuclide imaging;
Technetium Tc 99m dimercaptosuccinic acid;
Child
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2024;44(12):724-729
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the dose-response relationship of 99Tc m-dimercaptosuccinic acid (DMSA) in pediatric renal static imaging. Methods:A retrospective analysis of children (model group: n=199, 81 males, 118 females; validation group: n=30, 13 males, 17 females; all age: 1 month-14 years) who underwent 99Tc m-DMSA renal static imaging from January 2022 to November 2023 in Wuhan Children′s Hospital, Tongji Medical College, Huazhong University of Science and Technology were conducted. Post-administration radiation counts and related clinical data were collected. Imaging quality was evaluated using visual analogue scoring (VAS). ROC curve analysis was used to assess the relationship between radiation count intensity (RCI) and imaging quality. A nonlinear mixed-effects modeling method was employed to establish the dose-response relationship for 99Tc m-DMSA in pediatric renal static imaging. Internal and external validations of the model were performed. Final model was utilized to evaluate patient dosing protocols. Results:Body weight was considered as a significant determinant of the dose-response relationship in 99Tc m-DMSA renal static imaging( χ2 values: 120.79, 116.36, both P<0.05). ROC curve analysis showed that the quality of diagnostic images was acceptable when the anterior renal RCI was ≥32.61 (cut-point) and the posterior renal RCI was ≥35.46 (cut-point). Both internal and external validation results demonstrated that the dose-response model established exhibited good prediction performance. Based on the final model graph, the image quality could meet the requirements for clinical diagnosis. Conclusions:The 99Tc m-DMSA dose-response model for pediatric renal static imaging is successfully established. Individualized dosage based on the model can provide a reference for clinical individualized dosing decision-making.
