Characteristics and associated factors of left ventricular fibroblast activation on Al 18F-NOTA-FAPI imaging in patients with pulmonary hypertension
10.3760/cma.j.cn321828-20240701-00238
- VernacularTitle:Al 18F-NOTA-FAPI显像评价肺动脉高压患者左心室成纤维细胞活化特征及相关因素分析
- Author:
Bixi CHEN
1
;
Juanni GONG
;
Yang XU
;
Minfu YANG
Author Information
1. 首都医科大学附属北京朝阳医院核医学科，北京 100020
- Keywords:
Hypertension, pulmonary;
Quinolines;
Fibroblasts;
Fluorine radioisotopes;
Positron-emission tomography;
Tomography, X-ray computed
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2024;44(11):644-649
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate whether patients with pulmonary hypertension (PH) develop abnormal fibroblast activation protein (FAP) inhibitor (FAPI) uptake in the left ventricular free wall and to analyze its characteristics and significance.Methods:Al 18F-1, 4, 7-triazacyclononane-1, 4, 7-triacetic acid (NOTA)-FAPI-04 PET/CT images of 51 patients diagnosed with PH (24 males, 27 females; age: (48±21) years) and 10 healthy volunteers (4 males, 6 females; age: (59±12) years) from Beijing Chaoyang Hospital of Capital Medical University between February 2021 and January 2024 were retrospectively analyzed. Higher FAPI uptake in the left ventricular free wall than that in blood pool was defined as abnormal and SUV max, SUV mean, and total lesion FAP activity were quantitatively measured. Associated factors with FAPI uptake in the left ventricle were analyzed, and differences of clinical parameters between patients with and without abnormal left ventricular uptake were compared. Independent-sample t test and Mann-Whitney U test were used to compare differences between groups. Spearman rank correlation analysis was used for correlation analysis. Results:Abnormal FAPI uptake that was diffusely distributed in the left ventricular free wall was observed in 19 patients with PH. Total lesion FAP activity was positively correlated with peak mitral late-diastolic inflow velocity ( A) ( rs=0.696, P=0.001) and negatively correlated with peak mitral early-diastolic inflow velocity ( E)/ A and pulmonary vascular resistance (PVR) ( rs values: -0.629, -0.540, P values: 0.004, 0.017). Significant differences in E/ A (0.8(0.6, 1.1) vs 0.9(0.8, 1.4); z=-2.33, P=0.020), left ventricular end-systolic internal diameter ((25.7±2.6) vs (27.8±4.2) mm; t=-2.22, P=0.031), and left ventricular end-systolic volume ((26.7±7.3) vs (32.5±9.9) ml; t=-2.26, P=0.028) were found between patients with and without abnormal FAPI uptake in the left ventricle. Conclusion:In patients with PH, the left ventricular free wall develops diffuse abnormal uptake of FAPI, the extent of which is related to impaired left ventricular diastolic function.
