Progress in nanoparticle-based drug delivery system for targeted alpha-particle therapy
10.3760/cma.j.cn321828-20231023-00083
- VernacularTitle:基于靶向α核素治疗的纳米颗粒药物递送系统的研究进展
- Author:
Yushan HE
1
;
Mengya LIU
;
Xiujun QIN
Author Information
1. 中国辐射防护研究院放射医学与环境医学研究所，太原 030006
- Keywords:
Drug delivery systems;
Nanoparticles;
Radiotherapy;
Alpha particles;
Trends
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2024;44(10):637-640
- CountryChina
- Language:Chinese
-
Abstract:
By binding alpha-particle to ligands, targeted alpha-particle therapy illuminates the diseased tissue, using the radiographic energy and the range in the tissues of nuclides, and avoids damage to normal tissue to obtain the expected therapeutic effect, which is mainly used for tumor treatment. Targeted ligands are ideal drug carriers to deliver alpha-particle to the target to kill tumor cells accurately. In recent years, there have been some progresses in the research of α-radionuclide drug-based targeted ligands in nanomaterials, which have improved drug delivery and off-target effects. By summarizing the current research status, it is expected to provide reference for the development of alpha-particle drug delivery in the industry.
