Cutaneous Neonatal Lupus Erythematosus Associated with Brain Infarction.
- Author:
Soo Young LEE
1
;
Sanghoon LEE
;
Jang Yong JIN
;
Sung Shin KIM
;
Jae Ock PARK
;
Chang Hwi KIM
Author Information
1. Department of Pediatrics, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea. kimss@schmc.ac.kr
- Publication Type:Case Report
- Keywords:
Neonatal lupus erythematosus;
Brain infarction
- MeSH:
Antibodies;
Autoantibodies;
Brain;
Brain Infarction;
Female;
Heart Block;
Hematologic Diseases;
Humans;
Infant;
Infant, Newborn;
Lupus Erythematosus, Systemic;
Mothers;
Thrombocytopenia
- From:Soonchunhyang Medical Science
2011;17(2):118-121
- CountryRepublic of Korea
- Language:English
-
Abstract:
Neonatal lupus erythematosus (NLE) is an acquired autoimmune disorder caused by the transplacental passage of maternal autoantibodies, usually anti-Ro/SSA or anti-La/SSB antibodies, and less commonly U1-ribonucleoprotein. NLE usually involves a single organ, but multiple organ involvement has also been reported. Manifestations of NLE may include cutaneous lesions, congenital heart block, hematological diseases (anemia, thrombocytopenia, neutropenia), hepatic diseases (hepatitis, hepatosplenomegaly, cholestasis), and neurological diseases. Neurological involvement is very rare in infants with NLE. Here, we report a 2-day-old female neonate, born to a clinically asymptomatic mother, presenting with cutaneous lupus lesions and brain infarction as a neurological disease.
