Diagnostic value of 18F-FDG and 18F-FMZ PET/CT in the localization of focal cortical dysplasia
10.3760/cma.j.cn321828-20240101-00001
- VernacularTitle:18F－FDG、 18F－FMZ PET/CT对局灶性皮质发育不良的定位诊断价值
- Author:
Guanglei LI
1
,
2
;
Juanjuan HE
;
Weiqi BAO
;
Shize JIANG
;
Qi HUANG
;
Shuhua REN
;
Fang XIE
;
Jie HU
;
Yihui GUAN
Author Information
1. 复旦大学附属华山医院核医学&
2. PET中心，上海 200235
- Keywords:
Focal cortical dysplasia;
Flumazenil;
Fluorine radioisotopes;
Positron-emission tomography;
Tomography, X-ray computed;
Fluorodeoxyglucose F18
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2024;44(10):588-591
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the localization accuracy of interictal 18F-FDG and 18F-flumazenil (FMZ) PET/CT imaging for focal cortical dysplasia (FCD). Methods:A retrospective analysis was conducted on 22 patients (12 males, 10 females; age 8-36 years) with pathologically confirmed FCD who underwent surgical resection at Huashan Hospital, Fudan University from July 2021 to June 2023. All patients underwent 18F-FDG and 18F-FMZ PET/CT scans before surgery. Surgical pathological diagnosis was used as the gold standard. Visual scoring was used to analyze the images. The accuracy of the two imaging methods in the localization of FCD was compared, and subgroup analysis (FCD Ⅱa, FCD Ⅱb) of different pathological type was further performed. Paired- t test, χ2 test or Fisher′s exact test was used to analyze the data. Results:The visual score of 18F-FMZ PET/CT was higher than that of 18F-FDG (3.00±0.82 vs 2.27±0.92; t=4.17, P=0.020). The accuracy of interictal 18F-FMZ PET/CT was 77.27%(17/22), which was higher than that of 18F-FDG PET/CT (36.36%, 8/22; χ2=7.50, P=0.006). Subgroup analysis showed that within the cohort of patients diagnosed with FCD Ⅱa ( n=18), 18F-FMZ PET/CT outperformed 18F-FDG in terms of accuracy for localization (15/18 vs 6/18; P=0.006). Conclusion:Compared to 18F-FDG, 18F-FMZ PET/CT demonstrates clearer and more accurate identification of lesion borders, and exhibits higher precision, which provides valuable guidance for preoperative localization.
