Application of 99Tc m-pyrophosphate for typological diagnosis in cardiac amyloidosis

VernacularTitle:99Tc m-焦膦酸盐在心脏淀粉样变中的分型诊断应用
Author: Shuangli LIU ¹ ; Jianbo LI ; Xuemei WANG
Author Information

1. 内蒙古医科大学附属医院核医学科、内蒙古自治区分子影像学重点实验室，呼和浩特　010050
Keywords: Amyloidosis; Myocardium; Radionuclide imaging; Technetium Tc 99m pyrophosphate; Trends
From: Chinese Journal of Nuclear Medicine and Molecular Imaging 2024;44(9):568-571
CountryChina
Language:Chinese
Abstract: Amyloidosis is a metabolic disease characterized by the deposition of amyloidogenic fibrils in multiple organs, which causes structural disorders, leading to a decline in organ function and in the case of myocardial involvement, damage to the structure and function of the heart, which is the main cause of mortality. However, the disease is often misdiagnosed or underdiagnosed due to its insidious onset and lack of specificity in clinical manifestations. 99Tc m-pyrophosphate (PYP) SPECT is a noninvasive test that can not only identify cardiac amyloid deposits at an early stage but also provide a useful tool for the diagnosis of cardiac amyloidosis. This article briefly describes the traditional screening methods for cardiac amyloidosis, outlines their limitations, and focuses on the clinical diagnostic value of 99Tc m-PYP SPECT in cardiac amyloidosis.