Application of 18F-AlF-P16-093 PET combined with multiparametric MRI in the diagnosis of primary prostate cancer lesions: a head-to-head comparative study based on needle biopsy pathology
10.3760/cma.j.cn321828-20240607-00199
- VernacularTitle:18F-AlF-P16-093 PET联合多参数MRI在前列腺癌原发灶诊断中的应用：基于穿刺病理学的头对头研究
- Author:
Miao KE
1
;
Jinhui LIU
;
Shaonan ZHONG
;
Jing ZHANG
;
Mingzhao LI
;
Di GU
;
Ruiyue ZHAO
;
Xinlu WANG
Author Information
1. 广州医科大学附属第一医院核医学科，广州 510000
- Keywords:
Prostatic neoplasms;
Prostate-specific membrane antigen;
Positron-emission tomography;
Tomography, X-ray computed;
Multiparametric magnetic resonance imag
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2024;44(9):533-538
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the diagnostic efficacy of the novel prostate specific membrane antigen (PSMA)-targeted PET imaging agent 18F-AlF-P16-093 in combination with multiparametric MRI (mpMRI) for prostate cancer (PCa), and to explore its application in guiding transperineal puncture biopsy. Methods:A retrospective analysis was conducted on the clinical and pathological data of 36 patients diagnosed as PCa (age: 68-76 years) who underwent 18F-AlF-P16-093 PET/CT and mpMRI examinations at the First Affiliated Hospital of Guangzhou Medical University from August 2023 to March 2024. The entire prostate was divided into 12 regions based on biopsy localization. Imaging evaluations were performed using PET/CT and mpMRI at the lesion level, with biopsy pathology as the gold standard. The correlations between mpMRI scores, PET/CT scores and pathological diagnosis results were evaluated by Phi coefficient analysis. Diagnostic efficacy was assessed by ROC curve analysis. Logistic regression was used to determine the impact of bleeding on image interpretation. Results:18F-AlF-P16-093 PET/CT showed a moderate positive correlation with pathological diagnosis result ( Phi=0.415, P<0.001), which was superior to mpMRI ( Phi=0.338, P<0.001). The diagnostic efficacy of PET single-modality model was superior to mpMRI in all indicators. The combination of 18F-AlF-P16-093 PET/CT with mpMRI significantly improved diagnostic specificity and positive predictive value, with the diagnostic specificity of the PET+ T 2 weighted imaging (WI)+ diffusion WI (DWI) and PET+ T 2WI+ DWI+ apparent diffusion coefficient (ADC) combinations exceeding 90%, and the positive predictive value exceeding 80%. Bleeding did not significantly affect the diagnosis of PCa by mpMRI and PET/CT (odds ratio ( OR): 0.463-0.785, all P>0.05). Conclusion:18F-AlF-P16-093 PET/CT is superior to mpMRI in the detection and diagnostic efficacy of PCa lesions, and the combination of 18F-AlF-P16-093 PET with mpMRI can further improve diagnostic specificity and positive predictive value, which is of guiding significance for targeted prostate biopsy.
