Detection rate of 68Ga-PSMA-11 PET/CT and distribution characteristics of lesions in patients with biochemical recurrence after radical prostatectomy for prostate cancer
10.3760/cma.j.cn321828-20240627-00231
- VernacularTitle:68Ga-PSMA-11 PET/CT在前列腺癌根治术后生化复发患者中的检出率及病灶分布特征分析
- Author:
Qiaochu CHEN
1
;
Yining WANG
;
Xiang ZHOU
;
Cheng WANG
;
Haitao ZHAO
;
Liangrong WAN
;
Ruohua CHEN
;
Jianjun LIU
Author Information
1. 上海交通大学医学院附属仁济医院核医学科，上海 200127
- Keywords:
Prostatic neoplasms;
Recurrence;
Prostate-specific membrane antigen;
Isotope labeling;
Gallium radioisotopes;
Positron-emission tomography;
Tomography, X-ra
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2024;44(9):528-532
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the detection rate and distribution characteristics of lesions in patients with biochemical recurrence (BCR) after radical prostatectomy for prostate cancer by 68Ga-prostate specific membrane antigen (PSMA)-11 PET/CT. Methods:From January 2020 to March 2024, 68Ga-PSMA-11 PET/CT examination results of 172 patients (age (69.4±6.5) years) with BCR after radical prostatectomy in Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine were retrospectively analyzed. The relationship between prostate specific antigen (PSA) levels and 68Ga-PSMA-11 PET/CT detection rate was explored. The location and quantity of lesions detected by 68Ga-PSMA-11 PET/CT were analyzed in BCR patients with clear location after local treatment, and data were analyzed by Fisher exact test. Results:The detection rate of 68Ga-PSMA-11 PET/CT in patients with BCR was 70.35%(121/172). The positive detection rate increased with the increase of PSA level, with detection rates of 0.2 μg/L≤PSA<0.5 μg/L, 0.5 μg/L≤PSA<1.0 μg/L, 1.0 μg/L≤PSA<1.5 μg/L and PSA≥1.5 μg/L groups of 49.12%(28/57), 67.24%(39/58), 15/16 and 95.12%(39/41), respectively. After local treatment, 64 cases were diagnosed with 95 recurrent and metastatic lesions. Among them, 22(34.38%) had simple prostate bed recurrence, 23(35.94%) had simple lymph node metastasis, 7(10.94%) had simple bone metastasis, and 12(18.75%) had multi regional metastasis. The proportion of bone metastasis (18.75%, 12/64) was significantly lower than that of prostate bed recurrence and lymph node metastasis (both 50.00%(32/64); both P=0.002). Conclusions:68Ga-PSMA-11 PET/CT has a high detection rate in patients with BCR after radical prostatectomy, especially in patients with high PSA levels. The lesions are mainly distributed in the prostate bed and lymph nodes, while bone metastases are relatively rare, which provide a theoretical basis for the selection of more accurate treatment plans for BCR patients in the future.
