Prognostic value of metabolic parameters on 18F-FDG PET/CT imaging and clinical features in patients with squamous cell carcinoma of the cervix
10.3760/cma.j.cn321828-20230513-00130
- VernacularTitle:基线 18F－FDG PET/CT参数与临床参数对宫颈鳞状细胞癌预后的预测价值
- Author:
Yangyang WANG
1
;
Guangjie YANG
;
Wenlong YAN
;
Jie MA
;
Lei YAN
;
Yanli DUAN
;
Lianshuang XIA
;
Yan KONG
;
Yashuo YU
;
Zhenguang WANG
Author Information
1. 青岛大学附属医院核医学科PET中心，青岛 266100
- Keywords:
Uterine cervical neoplasms;
Carcinoma, squamous cell;
Positron-emission tomography;
Tomography, X-ray computed;
Fluorodeoxyglucose F18;
Prognosis
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2024;44(8):462-467
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To estimate the influence of metabolic parameters in 18F-FDG PET/CT and clinically relevant indicators on the prognosis of patients with cervical cancer. Methods:A total of 174 patients with cervical cancer (age (53.6±11.1) years) who underwent baseline 18F-FDG PET/CT examination in the Affiliated Hospital of Qingdao University from May 2011 to December 2020 were retrospectively collected. Metabolic parameters (metabolic tumor volume of primary lesion (MTV p), total lesion glycolysis of primary lesion (TLG p), MTV sum of total lesions (MTV total) in the whole body, TLG sum of total lesions (TLG total)) and clinical parameters (International Federation of Gynecology and Obstetrics (FIGO) stage, tumor maximum diameter ( Dmax), et al) were collected. Cox regression and Kaplan-Meier method were performed to evaluate the prognostic and predictive values of those parameters. Results:The follow-up time was 6-120 months, during which 52 patients (29.9%, 52/174) developed progression. The 5-year overall survival (OS), progression-free survival (PFS), local control (LC) and distant metastasis-free survival (DMFS) rates were 83.3%(145/174), 70.1%(122/174), 75.3%(131/174) and 82.8%(144/174), respectively. Cox regression showed that FIGO stage and MTV total were independent factors for predicting PFS, OS and LC (hazard ratio ( HR): 1.005-11.605, all P<0.05). FIGO stage and TLG total were independent factors for predicting DMFS ( HR: 1.002-12.258, all P<0.05). Conclusion:MTV total and FIGO stage are effective predictors of patients with cervical squamous cell carcinoma.
