Application and research progress of 68Ga-FAPIs in non-neoplastic diseases

VernacularTitle:68Ga－FAPIs在非肿瘤性疾病中的应用及研究进展
Author: Kang LI ¹ ; Xiaoyu CAI ; Yanzhu BIAN
Author Information

1. 河北省人民医院核医学科、河北省脑网络与认知障碍疾病重点实验室，石家庄　050051
Keywords: Quinolines; Gallium radioisotopes; Trends
From: Chinese Journal of Nuclear Medicine and Molecular Imaging 2024;44(7):431-435
CountryChina
Language:Chinese
Abstract: Fibroblast activation protein (FAP) is not only specifically expressed in cancer-associated fibroblasts (CAFs) of most neoplastic diseases, but also highly expressed in some diseases characterized by tissue remodeling. FAP inhibitors (FAPIs) PET can target the distribution of FAP in tissues and organs. Currently, 68Ga-FAPIs have played essential roles in the exploration, diagnosis, precise staging, targeted therapy, and clinical management of various malignant tumors. And 68Ga-FAPIs PET has shown the unique value and great potential in diagnosing and treating non-neoplastic diseases. This article aims to review the application and research progress of 68Ga-FAPIs in various non-neoplastic diseases such as cardiac imaging, immunoglobulin (Ig)G4-related disease, fibrosis, osteoarthropathy, and so on.