Current status of 68Ga-pentixafor imaging targeting chemokine receptor 4 in accessing inflammation after acute myocardial infarction
10.3760/cma.j.cn321828-20230112-00006
- VernacularTitle:68Ga-pentixafor趋化因子受体4显像评估急性心肌梗死后炎性反应的研究现状
- Author:
Li XU
1
;
Shaohui AN
;
Yuting ZHAO
;
Sijin LI
;
Ping WU
Author Information
1. 山西医科大学第一医院核医学科，太原 030001
- Keywords:
Myocardial infarction;
Inflammation;
Receptors, CXCR4;
Peptides, cyclic;
Trends
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2024;44(6):376-379
- CountryChina
- Language:Chinese
-
Abstract:
The excessive inflammatory response after acute myocardial infarction (AMI) is detrimental to the repair of the infarcted myocardium, and anti-inflammatory interventions at the peak of inflammation have shown efficacy. Therefore, longitudinal monitoring of myocardial inflammatory evolution after AMI in vivo is important for individualized risk prediction, anti-inflammatory treatment strategies guidance and further prognosis improvement. 68Ga-pentixafor, a promising novel probe targeting C-X-C chemokine receptor 4 (CXCR4) on the surface of inflammatory cells, with no special preparation before imaging, allows in vivo visualization of the inflammation intensity, extent and evolution in the infarcted myocardium as well as the response of other related extra-cardiac organs. This review referred to its radiopharmaceutical characteristics, research status, explorations and limitations in AMI.
