Experiences of patients with hematologic neoplasm regarding T-cell immunotherapy:a meta-synthesis review and inspiration for nursing care
10.3761/j.issn.0254-1769.2024.17.015
- VernacularTitle:血液系统恶性肿瘤患者对T细胞免疫治疗体验的Meta整合及护理启示
- Author:
Ying HUANG
1
;
Huafen WANG
;
Lifang SHAO
;
Li ZHENG
;
Danping SUN
;
Fangyuan LOU
;
Xiaofei YAO
Author Information
1. 310003 杭州市 浙江大学医学院附属第一医院感染科
- Keywords:
Hematologic Neoplasm;
Chimeric Antigen Receptor;
Immunotherapy;
Qualitative Research;
Meta-Synthesis;
Oncology Nursing
- From:
Chinese Journal of Nursing
2024;59(17):2147-2155
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study aims to systematically evaluate the experiences of patients with hematologic neoplasm undergoing chimeric antigen receptor T-cell(CAR-T)therapy and nursing care,and to provide a reference basis for healthcare providers to develop personalized intervention strategies.Methods PubMed,Web of Science,Embase,CINAHL,Cochrane Library,PsycINFO,Scopus,Australia Joanna Briggs Institute(JBI)EBP Database,China National Knowledge Infrastructure(CNKI),Wanfang Data,VIP Database,and China Biology Medicine(CBM)Database were systematically searched for qualitative studies on the experiences of patients with hematologic neoplasm undergoing CAR-T therapy and nursing care.The search period extended up to September 2023.The quality of the literature was reviewed according to the JBI Qualitative Assessment and Review Instrument,and a pooled analysis was applied to integrate the results.Results A total of 15 studies were included,generating 76 findings,which were then organized into 8 categories,resulting in 3 integrated findings.(1)Patients experienced conflicting emotions,with expectations often at odds with reality,leading to emotional fluctuations:expectations about treatment were entangled with concerns about risks;emotions fluctuated with expectations and actual experiences.(2)Patients experienced physical and social functional impairments,but as the disease eased,normal functioning recovered:rapid decline and improvement in physical functions;loss and recovery of social functions.(3)Patients desired access to professional guidance and psychosocial support.Conclusion Patients undergoing CAR-T therapy often contend with emotional conflicts.Changes in physical and social functions after the completion of treatment result in needs for seeking comprehensive medical and nursing support.It is recommended that healthcare providers conduct dynamic assessments and interventions regarding patients'emotional states before treatment,focus on early identification and management of adverse reactions after treatment,and offer continuous nursing services after discharge to enhance patients'confidence in participating in CAR-T therapy and improve their overall quality of life.
