Analysis of the development trajectory and influencing factors of endocrine therapy associated arthralgia in breast cancer patients
10.3761/j.issn.0254-1769.2024.14.010
- VernacularTitle:乳腺癌患者内分泌治疗相关骨关节疼痛发展轨迹及护理启示
- Author:
Lijie WANG
1
;
Siyi PENG
;
Jiejun CHEN
;
Tao WEI
;
Jiahui LIU
;
Meihong HU
;
Xuying LI
Author Information
1. 410013 长沙市 湖南省肿瘤医院护理部
- Keywords:
Breast Neoplasms;
Endocrine Therapy;
Aromatase Inhibitor;
Arthralgia;
Development Trajectory;
Growth Mixed Model;
Nursing Care
- From:
Chinese Journal of Nursing
2024;59(14):1732-1738
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the development trajectory and predictors of endocrine therapy associated arthralgia in breast cancer patients.Methods From January 2022 to July 2022,breast cancer patients in the breast medicine department or outpatients of a tertiary cancer hospital in Hunan Province were selected as respondents using a convenience sampling method.A baseline survey was conducted using the General Information Questionnaire,the Symptom Assessment Scale for Patients Treated with Endocrine Therapy for Breast Cancer,and the Self-Rating Anxiety Scale within 1 week prior to patient treatment.The Symptom Assessment Scale for Patients Treated with Endocrine Therapy for Breast Cancer was used to assess patients'arthralgia levels at 3,6,and 9 months after treatment,and data were analyzed using growth mixed model,univariate analysis of variance,and multiple logistic regression.Results A total of 418 breast cancer patients completed the follow-up,with 235 cases(56.22%)developing arthralgia.3 potential categories of arthralgia develop-ment trajectories were identified:high level-slowly increasing group(11.48%),low level-slowly increasing group(44.74%),and asymptomatic group(43.78%).The results of multifactorial analysis showed that anxiety,history of bone and joint disease,sleep duration,place of residence,monthly household income,and frequency of exercise were predictors of potential categories for the development of trajectory of arthralgia levels associated with endocrine therapy in breast cancer patients(P<0.05).Conclusion Arthralgia levels associated with endocrine therapy in breast cancer patients exhibit different trajec-tories,and clinical staff should emphasize the assessment and intervention of pain levels in patients with the anxiety,a history of bone and joint disease,poor sleep,poor finances,living in urban areas,and low frequency of exercise.
