Diagnosis and treatment experience of primary hepatic neuroendocrine neoplasm
10.3877/cma.j.issn.2095-3232.2018.03.012
- VernacularTitle:原发性肝脏神经内分泌肿瘤诊治经验
- Author:
Rongguang WEI
1
;
Zhou ZHOU
;
Haoran WU
;
Fahui CHENG
;
Xiaohui DUAN
;
Jianhui YANG
;
Bingzhang TIAN
;
Lixue ZHOU
;
Xianhai MAO
Author Information
1. 湖南省人民医院湖南师范大学第一附属医院肝胆外科
- Keywords:
Neuroendocrine neoplasms;
Liver neoplasms;
Hepatectomy
- From:
Chinese Journal of Hepatic Surgery（Electronic Edition）
2018;7(3):216-220
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the diagnosis, treatments for primary hepatic neuroendocrine neoplasm (NEN) and the efficacy.Methods Clinical data of 10 patients with primary hepatic NEN admitted in Hunan People's Hospital from March 2013 to December 2015 were analyzed retrospectively. The informed consents of all patients were obtained and the local ethical committee approval was received. There were 3 males and 7 females, aged 21-65 years old and the median age was 45 years old. According to the WHO classification for digestive system tumor 2010 version, there were 6 cases of neuroendocrine tumor (NET) G2, and 4 cases of neuroendocrine carcinoma (NEC). The clinical data, imaging characteristics, treatment, tumor pathological characteristics and prognosis of the patients were analyzed.Results Right upper abdominal pain was observed in 5 cases, right upper abdominal mass in 1 case, asthenia and anorexia1 in 1 case, and the remaining 3 cases were found with tumor when receiving routine physical examination. For imaging finding, 8 cases were diagnosed as isolated liver mass, and 2 were found with multiple masses in the liver. All of the 10 patients were confirmed by pathological examination, of which 3 were diagnosed by biopsy before operation, and 7 were confirmed with pathology after operation. 6 cases underwent radical resection, 1 case received microwave ablation, 1 underwent liver resection and intravenous chemotherapy pump implantation, 1 received chemotherapy alone and 1 abandoned treatment. To the submission date of this article, 6 cases survived without recurrence, 1 case suffered recurrence 1 month after operation with multiple lymph node metastases in the peritoneum and remained alive. 2 cases died, 1 of which died of no treatment after biopsy, 1 died of multiple distant metastases after 1 period of chemotherapy, and 1 lost follow-up.Conclusions There is no specific clinical manifestations of hepatic NEN. It should be confirmed by pathological examination. Surgical resection is the first choice for treatment. For patients with unresectable mass, TACE, microwave ablation and chemotherapy can be applied.
