Clinical significance of apolipoprotein F in prognosis of patients with hepatocellular carcinoma
10.3877/cma.j.issn.2095-3232.2018.01.018
- VernacularTitle:载脂蛋白F在肝细胞癌患者生存预后中的临床意义
- Author:
Boxuan ZHOU
1
;
Zhicheng YAO
;
Zhiyong XIONG
;
Ruixi LI
;
Tianxing DAI
;
Mingxing XU
;
Weiming FAN
;
Zheng ZHOU
;
Hao LIANG
;
Meihai DENG
;
Yunbiao LING
Author Information
1. 中山大学附属第三医院肝胆外科
- Keywords:
Carcinoma,hepatocellular;
Apolipoproteins;
Prognosis
- From:
Chinese Journal of Hepatic Surgery（Electronic Edition）
2018;7(1):73-76
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of apolipoprotein (Apo) F in hepatocellular carcinoma (HCC) and its application value in the prognosis of patients with HCC. Methods 50 HCC samples were procured from patients undergoing surgical resection in the Third Affiliated Hospital of Sun Yat-sen University between September 2015 and September 2016, and all the samples were confirmed by postoperative pathological examination. The informed consents of all patients were obtained and the local ethical committee approval was received. There were 37 males and 13 females, aged from 31-67 with a median age of 53 years old. The expression of ApoF mRNA in HCC tissues was detected by RT-PCR. The expression profile was analyzed by using data from the Gene Expression Omnibus (GEO). The expression of ApoF between two groups were compared by t test. Correlation analysis of clinical related parameter was conducted by Chi-square test, and survival prognosis was analyzed by Kaplan-Meier test and Log rank test. Results The average relative expression of ApoF mRNA in HCC tissues was 0.15±0.07, significantly lower than 0.55±0.09 in the adjacent tissues (t=-6.26, P<0.05). GEO online analysis showed that expression of ApoF was significantly correlated with the status of liver cirrhosis, and most HCC patients with liver cirrhosis presented low expression of ApoF (χ2=4.626, P<0.05). The 5-year disease-free survival was respectively 55.9% and 32.0% in ApoF high expression group and low expression group, where significant difference was observed (χ2=3.939, P<0.05). Conclusions Low expression of ApoF exists in HCC tissues, and it is related to the liver cirrhosis status of patients. Patients with low ApoF expression present poorer prognosis. ApoF plays a role in inhibiting the cancer.
