Application of simplified protocol combining with mesenchymal stem cell in ABO-incompatible liver transplant patients
10.3877/cma.j.issn.2095-3232.2016.06.009
- VernacularTitle:联合间充质干细胞简化方案在ABO血型不符肝移植患者中的应用
- Author:
Yingcai ZHANG
1
;
Jia YAO
;
Yinan DENG
;
Liang CHEN
;
Kaining ZENG
;
Qing YANG
;
Guoying WANG
;
Bingsheng FU
;
Tong ZHANG
;
Nan JIANG
;
Huimin YI
;
Genshu WANG
;
Jian ZHANG
;
Shuhong YI
;
Hua LI
;
Qi ZHANG
;
Yang YANG
;
Guihua CHEN
Author Information
1. 中山大学附属第三医院肝脏外科暨肝移植中心
- Keywords:
Mesenchymal stem cells;
Liver transplantation;
ABO blood-group system;
Blood group incompatibility;
Immunosuppression
- From:
Chinese Journal of Hepatic Surgery（Electronic Edition）
2016;5(6):380-384
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the safety and feasibility of a simplified protocol combining with mesenchymal stem cell (MSC) in ABO-incompatible (ABO-I) liver transplant patients. Methods Twelve ABO-I liver transplant patient who received the therapy of a simplified protocol combining with MSC in the Third Affiliated Hospital of Sun Yat-sen University between January 2014 and September 2015 were recruited in this prospective study. Ten cases were male and 2 were female, with a mean age of (39±13) years old. The informed consents of all patients or their families were obtained and the local ethical committee approval was received. A immunologic tolerance induction protocol, plasma exchange + rituximab + intravenous immunoglobin + MSC (simplified protocol combining with MSC and without splenectomy and graft local infusion), was used to prevent the antibody-mediated rejection (AMR) after liver transplantation (LT). The perioperative condition and postoperative outcome of the patients were observed. Results Three death cases were observed after LT including 2 cases died of multiple organ failure and 1 of gastrointestinal hemorrhage. The other cases survived. Two cases developed acute cellular rejection and no AMR case was observed. Biliary complication was observed in 3 cases, hepatic artery stenosis in 1 case and infection in 6 cases. Conclusion The simplified protocol combining with MSC is safe and effective in preventing the AMR after ABO-I LT.
