Inlfuencing factors of portal vein thrombosis after splenectomy in patients with portal hypertension
10.3877/cma.j.issn.2095-3232.2015.05.007
- VernacularTitle:门静脉高压症脾切除术后门静脉血栓发生影响因素分析
- Author:
Bo LIU
1
;
Zhicheng YAO
;
Kunpeng HU
;
Jizong LIN
;
He HUANG
;
Shilei XU
;
Qingliang WANG
;
Peng ZHANG
;
Peisheng YANG
Author Information
1. 中山大学附属第三医院岭南医院普通外科
- Keywords:
Splenectomy;
Venous thrombosis;
Hypertension,portal;
Platelet count;
D-dimer
- From:
Chinese Journal of Hepatic Surgery（Electronic Edition）
2015;(5):284-287
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the influencing factors of portal vein thrombosis (PVT) after splenectomy in patients with portal hypertension.MethodsClinical data of 67 patients with liver cirrhosis and portal hypertension undergoing splenectomy + endoscopicvariceal ligation in Lingnan Hospital, the Third Affiliated Hospital of Sun Yat-sen University between March 2012 and April 2015 were retrospectively studied. Among the 67 patients, 47 were males and 20 were females with the average age of (47±8) years old. Thirty-five patients underwent laparoscopic splenectomy and 32 patients underwent open splenectomy. The informed consents of all patients were obtained and the local ethical committee approval had been received. The patients were divided into the PVT group and the non-PVT group according to whether PVT developed after surgery. The influencing factors of PVT in two groups were compared. The comparison of the influencing factors of PVT was conducted usingt test or chi-square test.ResultsEleven cases developed PVT after splenectomy with the incidenceof 16% (11/67) including 6 cases of laparoscopic splenectomy and 5 of open splenectomy. The incidence of PVT was associated with Plt and the concentration of D-dimer in blood circulation. Blood Plt of the PVT group was (739±39) ×109/L, which was significantly higher than (318±51)×109/L of the non-PVT group (t=14.678,P<0.05). The concentration of D-dimer of the PVT group was (7.4±1.1) mg/L, which was significantly higher than (4.0±0.9) mg/L of the non-PVT group (t=5.458, P<0.05). The incidence of PVT was not associated with surgical procedure (χ2=0.028,P>0.05).Conclusion The incidence of PVT after splenectomy is associated with Plt and the concentration of D-dimer and is not associated with surgical procedure.
