Survival prognostic analysis in patients with hepatocellular carcinoma after radical resection
10.3877/cma.j.issn.2095-3232.2015.01.010
- VernacularTitle:肝细胞癌根治性肝切除术后患者生存预后分析
- Author:
Yushan CHEN
1
;
Muyao CHEN
;
Miaoqing MAI
;
Peifen CHEN
;
Lianying HU
Author Information
1. 中山大学附属肿瘤防治中心放疗科 1
- Keywords:
Carcinoma,hepatocellular;
Hepatectomy;
Prognosis
- From:
Chinese Journal of Hepatic Surgery（Electronic Edition）
2015;(1):35-37
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the survival prognostic influencing factors of patients with hepatocellular carcinoma (HCC) after radical resection. Methods Clinical data of 1 102 patients with HCC undergoing radical resection in Sun Yat-sen University Cancer Center from January 2006 to June 2012 were analyzed retrospectively. There were 872 males and 230 females with a mean age of (55±15) years old. The informed consents of all patients were obtained and local ethical committee approval had been received. All the patients were followed up after operation. The cumulative survival rate was estimated using Kaplan-Meier method according to the follow-up results. Clinical indexes such as age, gender, history of viral hepatitis B, family history of HCC, serum alpha fetoprotein (AFP), serum alkaline phosphatase (ALP), Child-Pugh liver function grading, tumor diameter, portal vein tumor thrombus, tumor differentiation, vessel invasion, lymph node metastasis, distant metastasis, tumor node metastasis (TNM) staging were enrolled as prognostic impact factors and were analyzed using Log-rank test and Cox proportional hazards model. Results The survival time was 4-114 months with a median of 70 months for the patients with HCC after radical resection. The 1-, 3-, 5-year cumulative survival rates were 88.9%, 73.2%, 52.3%. Tumor diameter>4 cm, positive serum AFP, poor tumor differentiation were the independent risk factors for the prognosis of patients with HCC after radical resection (RR=1.951, 3.498, 3.781;P<0.05). Conclusion Tumor diameter>4 cm, positive serum AFP, poor tumor differentiation are the independent risk factors inlfuencing the prognosis of patients with HCC after radical resection.
