Clinical characteristics and prognostic factors of intrahepatic cholangiocarcinoma with positive AFP
10.3877/cma.j.issn.2095-3232.2014.06.009
- VernacularTitle:AFP阳性肝内胆管细胞癌患者的临床特征及其预后影响因素
- Author:
Qingliang WANG
1
;
Shilei XU
;
Peng ZHANG
;
He HUANG
;
Zhicheng YAO
;
Peisheng YANG
;
Bo LIU
Author Information
1. 中山大学附属第三医院普通外科
- Keywords:
Bile duct neoplasms;
alpha-fetoproteins;
Liver cirrhosis;
Hepatectomy
- From:
Chinese Journal of Hepatic Surgery（Electronic Edition）
2014;(6):39-42
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the clinical characteristics and prognostic factors in intrahepatic cholangiocarcinoma (ICC) patients with positive alpha-fetoprotein (AFP).MethodsClinical data of 57 patients with ICC in the Third Afifliated Hospital of Sun Yat-sen University from September 2004 to December 2013 were analyzed retrospectively. The informed consents of all patients were obtained and the ethical committee approval was received. There were 34 males and 23 females with an average age of (52±13) years old. According to serum AFP test result after admission in hospital, the patients were divided into AFP positive group (n=16) and AFP negative group (n=41). The difference of clinicopathological factors between two groups such as age, gender, hepatitis B surface antigen (HBsAg), liver cirrhosis, biliary lesions, preoperative carbohydrate antigen 19-9 (CA19-9), surgical procedure, metastastic lymph nodes, histological differentiation degree were compared byt-test , Chi-square test or Fisher's exact probability test. The patients were followed up and the survival of two groups was recorded. Prognostic factors analysis was conducted by Log-rank test and Cox proportional hazards regression model.ResultsMale patients accounted for 94% (15/16) in AFP positive group, which was signiifcantly higher than that in AFP negative group [46%(19/41)] (χ2=10.747,P<0.05). Patients complicated with liver cirrhosis accounted for 88% (14/16) , which was significantly higher than that in AFP negative group [37% (15/41)] (χ2=11.937,P<0.05). No patients were complicated with biliary lesions in AFP positive group but in AFP negative group, 12 cases were complicated with biliary lesions, where signiifcant difference was observed between two groups (P<0.05). Surgical procedure was the independent risk factor for patients in AFP positive group. Patients undergoing radical resection had better prognosis (RR=26.813,P<0.05).ConclusionsICC patients with positive AFP are mostly complicated with liver cirrhosis but a low incidence of biliary lesions. Surgical procedure is the independent risk factor for the prognosis. Radical resection is an effective way to improve the prognosis of ICC patients with positive AFP.
