Preoperative platelet count in predicting prognosis of patients with hepatocellular carcinoma after hepatectomy
10.3877/cma.j.issn.2095-3232.2014.02.006
- VernacularTitle:术前血小板计数在评价肝细胞癌切除术后患者生存预后中的价值
- Author:
Pinzhu HUANG
1
,
2
;
Chunhong LIU
;
Guihua CHEN
;
Bo LIU
;
Zemin HU
;
Jiliang QIU
;
Yadi LIAO
;
Binkui LI
;
Yun ZHENG
;
Yunfei YUAN
Author Information
1. 510060 广州，中山大学肿瘤防治中心肝胆肿瘤外科
2. 中山大学附属第三医院岭南医院普通外科
- Keywords:
Carcinoma,hepatocellular;
Blood platelets;
Survival analysis;
Prognosis
- From:
Chinese Journal of Hepatic Surgery（Electronic Edition）
2014;(2):88-91
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of preoperative platelet count (Plt) in predicting prognosis of patients with hepatocellular carcinoma (HCC) after hepatectomy. Methods Clinical data of 399 patients who underwent hepatic resection for HCC in Department of Hepatobiliary Oncology, Sun Yat-sen University Cancer Center from January 1987 to December 1994 were analyzed retrospectively. The informed consents of all patients were obtained and the ethics committee approval was received. Of the 399 patients, 356 cases were male, and 43 cases were female with age ranging from 21 to 78 years old and a median age of 48 years old. The relations between preoperative Plt and patients' gender, age, gamma-glutamyl transpeptidase (GGT), hepatitis B surface antigen (HBsAg), alpha fetal protein (AFP), cirrhosis, tumor encapsulation, tumor diameter, tumor number, vascular invasion and histological differentiation were observed. Patients were divided into 3 groups according to the level of preoperative Plt:group 1 (<100×109/L, n=41), group 2 (100×109/L-300×109/L, n=321), group 3 (>300×109/L, n=37). Survival analysis of patients in 3 groups was conducted. The relations between preoperative Plt and clinicopathological parameters were compared using t test. Survival analysis was conducted using Kaplan-Meier method and Log-rank test. Survival prognosis was analyzed using Cox's proportional hazard model. Results Preoperative Plt was associated with HBsAg, AFP, and tumor diameter (t=2.069, 2.222,-3.911;P<0.05). The 5-, 10-, 15-year cumulative survival rates were 41.2%, 25.2%, 11.8%in group 1, 33.7%, 23.0%, 18.1%in group 2, and 11.4%, 8.6%, 5.7%in group 3 respectively. The survival rate in group 3 was signiifcantly lower than those in group 1 and group 2 (χ2=5.706, 11.361;P<0.05). Increasing preoperative Plt was an independent risk factor for postoperative prognosis. The prognosis in group 3 was poorer than those in group 1 and group 2 (HR=1.761, 1.845;P<0.05). Conclusions Increasing preoperative Plt is an independent risk factor for postoperative prognosis of patients with HCC after hepatectomy. Patients with increasing preoperative Plt have poor prognosis.
