Progress in the diagnosis and treatment of dedifferentiated chondrosarcoma
10.3760/cma.j.cn121113-20240612-00343
- VernacularTitle:去分化软骨肉瘤诊疗进展
- Author:
Zibo XU
1
;
Zhuoyu LI
;
Weifeng LIU
Author Information
1. 首都医科大学附属北京积水潭医院骨肿瘤科，国家骨科医学中心，北京 100035
- Keywords:
Chondrosarcoma;
Diagnosis;
Surgical procedures, operative;
Prognosis
- From:
Chinese Journal of Orthopaedics
2024;44(20):1371-1376
- CountryChina
- Language:Chinese
-
Abstract:
Dedifferentiated chondrosarcoma (DDCS) is a rare, high-grade variant of chondrosarcoma with a poor prognosis, making its diagnosis and treatment particularly challenging. Comprehensive imaging plays a crucial role in the initial diagnosis, while image-guided biopsy remains an essential tool for confirming the disease. Surgical intervention remains the primary treatment modality, and selecting an appropriate surgical approach based on the patient's condition is critical. Achieving wide or radical surgical margins is vital for reducing the risk of local recurrence and distant metastasis. Unfortunately, DDCS demonstrates limited sensitivity to both radiotherapy and chemotherapy, and current advancements in these therapeutic approaches remain in the exploratory phase. In recent years, efforts by both domestic and international researchers to incorporate novel therapies such as immunotherapy and targeted therapy have yielded promising, results. Given the rarity of DDCS, existing clinical studies are largely limited to case reports or small retrospective studies, highlighting the need for larger, more robust studies to strengthen the evidence base. This review aims to summarize the latest progress in the diagnosis and treatment of DDCS, offering insights to guide clinical practice and inform future research directions.
