Research progress of reactive oxygen scavenging hydrogel in osteoarthritis
10.3760/cma.j.cn121113-20240423-00241
- VernacularTitle:活性氧清除性水凝胶在骨关节炎治疗中的研究进展
- Author:
Pengfei HUANG
1
;
Junjie ZHAO
;
Zhaokun ZHANG
;
Xiyu WANG
;
Yuhao ZHAO
;
Haiyan ZHAO
Author Information
1. 兰州大学第一临床医学院，兰州 730000
- Keywords:
Osteoarthritis;
Reactive oxygen species;
Biocompatible materials;
Hydrogels;
Oxidative stress
- From:
Chinese Journal of Orthopaedics
2024;44(17):1184-1190
- CountryChina
- Language:Chinese
-
Abstract:
Reactive oxygen species play a crucial role in maintaining metabolic balance in the body. They are not only important mediators in maintaining a normal physiological environment, but also important triggers for the occurrence and development of many diseases. Osteoarthritis is the most common degenerative joint disease at present. Due to the aging population, extended life expectancy and obesity, the incidence rate and prevalence of osteoarthritis have increased year by year. Recent studies on osteoarthritis show that reactive oxygen species play a crucial role in its occurrence and development, and are key factors leading to extracellular matrix degradation, mitochondrial dysfunction, chondrocyte apoptosis and the progress of osteoarthritis. For osteoarthritis, moderate levels of reactive oxygen species can promote the proliferation of chondrocytes and the formation of cartilage matrix. However, excessive accumulation of reactive oxygen species can induce oxidative stress, leading to degeneration of chondrocytes and breakdown of cartilage matrix, ultimately resulting in the occurrence of osteoarthritis and many other metabolic diseases. In recent years, hydrogels have attracted attention as new biomaterials for the treatment of osteoarthritis. Reactive oxygen scavenging hydrogels are a new type of polymer biomaterials with drug intelligent delivery function that can regulate tissue oxidative stress and inflammatory reaction. They mainly include traditional reactive oxygen scavenging hydrogels with the main function of loading reactive oxygen scavenging drugs and reactive oxygen responsive hydrogels with reactive oxygen responsive groups. The former mainly uses slow-release drugs with reactive oxygen species scavenging properties encapsulated in it to treat osteoarthritis, while the latter can not only clear the reactive oxygen species generated during the occurrence and development of osteoarthritis by breaking the reactive oxygen species responsive groups, but also responsively deliver various drugs for treating osteoarthritis. Reactive oxygen scavenging hydrogels have a good prospect in the treatment of osteoarthritis and repair.
