An Experimental Study on the Mechanism of Respiratory Stimulation by Remeflin®.
- Author:
II Yong KWAK
1
;
Kun Il LEE
Author Information
- Publication Type:Original Article
- MeSH: Adult; Carbon Dioxide; Humans; Hydrogen-Ion Concentration; Male; Morphine; Respiration; Respiratory Center; Respiratory Insufficiency; Respiratory Rate; Sodium Chloride; Tidal Volume; Ventilation; Volunteers
- From:Korean Journal of Anesthesiology 1976;9(1):9-15
- CountryRepublic of Korea
- Language:Korean
- Abstract: To ten male volunteers, 25 to 35 years old and without any known disease, physiological saline solution (placebo) 1 ml, morphine 10mg, and Remeflin 16 mg were administered intramuscularly. Effects of tbese agents upon ventilation at rest and respiratory response to carbon dioxide rebreathing were studied. The results are as follows: 1) Morphine significantly decreased respiratory rate, minute volume, and Pao2 and increased Paco2 without significantly affecting either tidal volume or arterial pH. 2) In morphine-induced respiratory depression, Remeflin improved ventilation by significantly increasing tidal volume and minute volume with resultant increase in Pao2 and decrease in Paco2, Remeflin did not significantly alter respiratory rate and arterial pH 3) Morphine displaced respiratory response curve to carbon dioxide obtained with placebo 7 torr to the right and Remeflin 6 torr to the left. No changes in slope of the curves were observed. 4) It is concluded that Remeflin stimlulatea respiration by directly acting upon the respiratory center.
