Analysis of the influencing factors on low liver regeneration in patients with hilar cholangiocarcinoma after portal venous embolizaion
10.3760/cma.j.cn113884-20240604-00172
- VernacularTitle:肝门部胆管癌患者门静脉栓塞术后肝脏低再生的影响因素分析
- Author:
Guangbo LIU
1
;
Jianbin CHEN
;
Huibo ZHAO
;
Zhantao XIE
;
Gaofeng TANG
;
Yongfeng CHEN
;
Sidong WEI
;
Guoyong CHEN
Author Information
1. 河南省人民医院（郑州大学人民医院）肝胆胰腺外科，郑州 450000
- Keywords:
Klatskin tumor;
Liver regeneration;
Risk factors;
Portal vein embolization
- From:
Chinese Journal of Hepatobiliary Surgery
2024;30(11):836-839
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the influencing factors of low liver regeneration in patients with hilar cholangiocarcinoma (HCCA) after portal vein embolization (PVE).Method:Clinical data of 62 patients with HCCA undergoing PVE at Henan Provincial People's Hospital (People's Hospital of Zhengzhou University) from January 2019 to March 2024 were retrospectively analyzed, including 33 males and 29 females, aged (59.1±10.3) years. Patients were divided into two groups based on the median regeneration rate of remnant liver volume (28.6%) three weeks after PVE: low regeneration ( n=31, <28.6%) and high regeneration group ( n=31, ≥28.6%). The proportion of lymph node metastasis, history of alcohol consumption, liver fibrosis, biliary tract infection, alkaline phosphatase (ALP), and tumor necrosis factor-α (TNF-α) were compared between two groups. Multivariate logistic regression analysis was used to indentify the influencing factors of low liver regeneration in patients with HCCA after PVE surgery. Results:The proportion of lymph node metastasis, history of alcohol consumption, liver fibrosis, biliary tract infection, ALP, and level of TNF-α were higher in the low regeneration group than those in the high regeneration group (all P<0.05). Multivariate logistic regression analysis showed that patients with regional lymph node metastasis ( OR=2.561, 95% CI: 1.265-5.185), history of alcohol consumption ( OR=2.616, 95% CI: 1.321-5.181), liver fibrosis ( OR=2.351, 95% CI: 1.265-4.369), biliary tract infection ( OR=2.461, 95% CI: 1.226-4.940), elevated level of ALP ( OR=2.687, 95% CI: 1.351-5.344), and elevated level of TNF-α ( OR=2.781, 95% CI: 1.452-5.326) had an increased risk of low liver regeneration after PVE (all P<0.05). Conclusion:Regional lymph node metastasis, history of alcohol consumption, liver fibrosis, biliary tract infection, and elevated ALP and TNF-α are risk factors for low liver regeneration in patients with HCCA after PVE surgery, which should be noted in clinical practice.
