Research progress of short-chain fatty acid in liver ischemia-reperfusion injury
10.3760/cma.j.cn113884-20240716-00214
- VernacularTitle:短链脂肪酸在肝缺血再灌注损伤中的研究进展
- Author:
Wenjing XU
1
;
Wen HOU
;
Shuang YANG
;
Jiansen LU
;
Decheng CHEN
;
Fei WANG
;
Lei LIU
Author Information
1. 天津医科大学一中心临床学院，天津 300070
- Keywords:
Liver;
Ischemia-reperfusion injury;
Short-chain fatty acids;
Oxidative stress;
Immune responses
- From:
Chinese Journal of Hepatobiliary Surgery
2024;30(10):787-790
- CountryChina
- Language:Chinese
-
Abstract:
Liver ischemia-reperfusion injury (IRI) is a significant factor contributing to liver dysfunction following surgical procedures such as liver transplantation and hepatectomy, and its pathogenesis is closely associated with oxidative stress and immune responses. However, effective prevention and therapeutic strategies are still lacking. Short-chain fatty acids (SCFAs), primarily produced by the fermentation of gut microbiota, are the major source of these acids in the human body. Research has indicated that SCFAs play a significant role in oxidative stress and immune response. This review primarily focuses on the advancements on the role of SCFAs, the main metabolic byproducts of gut microbiota, in liver IRI, with a view to provide insights for the development of prevention and treatment strategies for liver IRI.
