Association between acute, chronic, alcoholic pancreatitis and pancreatic cancer: based on two-sample Mendelian randomization
10.3760/cma.j.cn113884-20240605-00175
- VernacularTitle:酒精性及急、慢性胰腺炎与胰腺癌的相关性研究：基于双样本孟德尔随机化
- Author:
Yuting XIAO
1
;
Ting DAI
;
Dan LIU
;
Honghui ZHANG
Author Information
1. 湖南省人民医院肝胆外科，长沙 410005
- Keywords:
Pancreatitis;
Pancreatic cancer;
Mendelian randomization
- From:
Chinese Journal of Hepatobiliary Surgery
2024;30(10):771-775
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore whether acute pancreatitis, chronic pancreatitis and alcoholic pancreatitis are related to the incidence of pancreatic cancer in Mendelian randomization study.Methods:Using data from a genome-wide association study (GWAS) of European ancestry, the pancreatic cancer data in the UK population is obtained from the GWAS. Acute, chronic, and alcoholic pancreatitis data in the Finnish population is obtained from the Finnish database version R10. The correlation between acute, chro-nic pancreatitis, alcoholic pancreatitis and pancreatic cancer was analyzed by two-sample Mendelian randomization through five Mendelian analysis methods mainly based on inverse variance weighting. Q heterogeneity test, pleiotropy test and reverse test were carried out to ensure the robustness of the results.Results:Chronic pancreatitis was positively associated with pancreatic cancer ( OR=1.332, 95% CI: 1.044-1.698, P=0.021). The results of Q heterogeneity test, pleiotropy test and reverse Mendelian randomization showed that the conclusions were reliability, all P>0.05. While acute pancreatitis ( P=0.953), acute alcoholic pancreatitis ( P=0.862) and chronic alcoholic pancreatitis ( P=0.682) were not significantly associated with pancreatic cancer. Conclusion:This study further confirmed the strong correlation between chronic pancreatitis and pancreatic cancer at the genetic level.
