Effect of TACE with drug-loaded microspheres versus with iodinated oil emulsion on liver fibrosis
10.3760/cma.j.cn113884-20240523-00155
- VernacularTitle:载药微球的TACE与碘化油乳剂的TACE对肝纤维化的影响
- Author:
Daqian HAN
1
;
Hao LI
;
Manzhou WANG
;
Chao LIANG
;
Jiacheng WANG
;
Wenze XU
;
Yangyang NIU
;
Donglin KUANG
;
Jianzhuang REN
;
Xuhua DUAN
Author Information
1. 郑州大学第一附属医院放射介入科，郑州 450000
- Keywords:
Liver neoplasms;
Chemoembolism;
Liver function;
Liver fibrosis
- From:
Chinese Journal of Hepatobiliary Surgery
2024;30(10):738-743
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the effects of drug-loaded microsphere TACE (D-TACE) and iodinated oil emulsion TACE (cTACE) on liver fibrosis in the treatment of advanced hepatocellular carcinoma (HCC).Methods:Clinical data of 113 patients with HCC treated with D-TACE or cTACE at the First Affiliated Hospital of Zhengzhou University from October 2019 to September 2020 were retrospectively analyzed, including 96 males and 17 females, aged (56.8±9.8) years old. According to treatment protocol, patients were divided into two groups: the D-TACE group ( n=57) and the cTACE group ( n=56). Liver fibrosis panel, fibrosis index (FIB-4), aspartate aminotransferase to platelet ratio index (APRI), and liver stiffness measurement (LSM) were compared between the groups at four timepoints: pre-treatment, one month after the first TACE, one month after the second TACE, and 12 months after the first TACE. Follow-ups were conducted through outpatient visits or telephone reviews to assess patient survivals. Data including the progression-free survival (PFS) and number of TACE sessions were compared between the two groups. Results:The D-TACE group received 2.84±1.12 sessions of treatment during the observation period, compared to 4.05±1.44 sessions of cTACE group ( t=4.94, P<0.001). The median PFS in D-TACE and cTACE groups were 10.0 and 5.0 months, respectively ( P<0.001). At one month after the second TACE and at 12 months after the first TACE, patients in cTACE group had a higher serum levels of fibrosis markers including hyaluronic acid, type IV collagen, type III procollagen N peptide and laminin than those in D-TACE group (all P<0.05). At the same timepoints, patients in cTACE group also had higher APRI, FIB-4 and LSM than those in D-TACE group (all P<0.05). Conclusion:Compared to cTACE, patients in D-TACE group received fewer sessions of treatment during the first year after initial TACE, and the degree of liver fibrosis was also lower in D-TACE group.
